The degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs

The degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs

Abstract Polyacrylic acid (PAA) with different concentrations of cross-linker was instilled into the trachea of rats to examine the effect of PAA crosslink density on lung disorders. Methods: F344 rats were intratracheally exposed to low and high doses of PAA with cross-linker concentrations of 0.1,...

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Main Authors: Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Toshiki Morimoto, Yasuyuki Higashi, Ke-Yong Wang, Hidenori Higashi, Takuma Kojima, Kazuo Sakurai, Jun-ichi Takeshita, Akihiro Moriyama, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Polyacrylic acid
Cross-link
Intratracheal instillation
Pulmonary toxicity
Fibrosis
Rat
Online Access:https://doi.org/10.1038/s41598-025-87174-6
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