From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes

From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes

Abstract Peptidoglycan hydrolases are promising alternatives for combating pathogens due to their specificity and potent bacteriolytic activity. In this study, a novel M23 peptidase from Streptococcus thermophilus NCTC10353, designated StM23, was discovered and characterized. It exhibited antibacter...

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Bibliographic Details
Main Authors: Magdalena Kaus-Drobek, Marzena Nowacka, Magdalena Gewartowska, Małgorzata Korzeniowska nee Wiweger, Merete Rusås Jensen, Trond Møretrø, Even Heir, Elżbieta Nowak, Izabela Sabała
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
M23 peptidases
Peptidoglycan hydrolases
Listeria monocytogenes
Biofilm eradication
Antimicrobial agents
Online Access:https://doi.org/10.1038/s41598-025-99141-2
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