Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction

Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction

Abstract Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar K d values as determined by a competitive fluorescence polarization assay. A d...

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Main Authors: Edvin Purić, Mujtaba Hassan, Fredrik Sjövall, Tihomir Tomašič, Mojca Pevec, Jurij Lah, Jaume Adrover Forteza, Anders Sundin, Hakon Leffler, Ulf J. Nilsson, Derek T. Logan, Marko Anderluh
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01458-6
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