APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

Aβ is believed to play a significant role in synaptic degeneration observed in Alzheimer’s disease and is primarily investigated as a secreted peptide. However, the contribution of intracellular Aβ or other cleavage products of its precursor protein (APP) to synaptic loss remains uncertain. In this...

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Bibliographic Details
Main Authors: Mengxun Luo, Jia Zhou, Cailu Sun, Wanjia Chen, Chaoying Fu, Chenfang Si, Yaoyang Zhang, Yang Geng, Yelin Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
Alzheimer's disease
amyloid precursor protein
synapse
β-CTF
endosome
Online Access:https://elifesciences.org/articles/100968
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https://elifesciences.org/articles/100968

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