Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis
We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels...
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Thieme Revinter Publicações
2011-02-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100018&lng=en&tlng=en |
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| author | Pedro Paulo Vasconcellos Varella Joselita Ferreira Carvalho Santiago Henrique Carrete Jr. Elisa Mieko Suemitsu Higa Elza Márcia Targas Yacubian Ricardo Silva Centeno Luís Otávio Sales Ferreira Caboclo Eduardo Ferreira de Castro Neto Mauro Canzian Débora Amado Esper Abrão Cavalheiro Maria da Graça Naffah- Mazzacoratti |
| author_facet | Pedro Paulo Vasconcellos Varella Joselita Ferreira Carvalho Santiago Henrique Carrete Jr. Elisa Mieko Suemitsu Higa Elza Márcia Targas Yacubian Ricardo Silva Centeno Luís Otávio Sales Ferreira Caboclo Eduardo Ferreira de Castro Neto Mauro Canzian Débora Amado Esper Abrão Cavalheiro Maria da Graça Naffah- Mazzacoratti |
| author_sort | Pedro Paulo Vasconcellos Varella |
| collection | DOAJ |
| description | We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS. |
| format | Article |
| id | doaj-art-b92cf25bca484bffa62b74b1e1b9d5b7 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-02-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-b92cf25bca484bffa62b74b1e1b9d5b72025-08-20T03:04:48ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-02-01691919910.1590/S0004-282X2011000100018S0004-282X2011000100018Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosisPedro Paulo Vasconcellos Varella0Joselita Ferreira Carvalho Santiago1Henrique Carrete Jr.2Elisa Mieko Suemitsu Higa3Elza Márcia Targas Yacubian4Ricardo Silva Centeno5Luís Otávio Sales Ferreira Caboclo6Eduardo Ferreira de Castro Neto7Mauro Canzian8Débora Amado9Esper Abrão Cavalheiro10Maria da Graça Naffah- Mazzacoratti11Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloWe investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100018&lng=en&tlng=ensinal hipocampal em FLAIRcitocinasNOglutamatoesclerose hipocampal |
| spellingShingle | Pedro Paulo Vasconcellos Varella Joselita Ferreira Carvalho Santiago Henrique Carrete Jr. Elisa Mieko Suemitsu Higa Elza Márcia Targas Yacubian Ricardo Silva Centeno Luís Otávio Sales Ferreira Caboclo Eduardo Ferreira de Castro Neto Mauro Canzian Débora Amado Esper Abrão Cavalheiro Maria da Graça Naffah- Mazzacoratti Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis Arquivos de Neuro-Psiquiatria sinal hipocampal em FLAIR citocinas NO glutamato esclerose hipocampal |
| title | Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis |
| title_full | Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis |
| title_fullStr | Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis |
| title_full_unstemmed | Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis |
| title_short | Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis |
| title_sort | relationship between fluid attenuated inversion recovery flair signal intensity and inflammatory mediator s levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis |
| topic | sinal hipocampal em FLAIR citocinas NO glutamato esclerose hipocampal |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100018&lng=en&tlng=en |
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