Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations

Somatic activating mutations in PIK3CA are common drivers of vascular and lymphatic malformations. Despite common biophysical signatures of tissues susceptible to lesion formation, including compliant extracellular matrix and low rates of perfusion, lesions vary in clinical presentation from localiz...

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Bibliographic Details
Main Authors: Wen Yih Aw, Aanya Sawhney, Mitesh Rathod, Chloe P. Whitworth, Elizabeth L. Doherty, Ethan Madden, Jingming Lu, Kaden Westphal, Ryan Stack, William J. Polacheck
Format: Article
Language:English
Published: AIP Publishing LLC 2025-03-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0234507
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