Role of miR-144-5p in modulating lipid metabolism and potentially alleviating obesity via the PGC-1α/AMPK pathway

Role of miR-144-5p in modulating lipid metabolism and potentially alleviating obesity via the PGC-1α/AMPK pathway

IntroductionMiR-144-5p is differentially expressed in plasma exosomes from Bactrian camels of varying body sizes, with GO and KEGG analyses indicating that its target genes play crucial roles in lipid metabolism. PGC-1α, confirmed as a key target through RNA pull-down and dual-luciferase reporter as...

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Main Authors: Siriguleng Yu, Chaoqun Liu, Hong Lv, Zhijun Guo, Hongqiang Yao, Xin Wen, Ying Xiu, Wa Gao, Ziyi Li, Wen Yu, Yaru Niu, Junjian Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Veterinary Science
Subjects:
Bactrian camel
exosome
metabolism
miR-144-5p
PGC-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1477593/full
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https://www.frontiersin.org/articles/10.3389/fvets.2025.1477593/full

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