Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarction

Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarction

Abstract Myocardial infarction (MI) is a life-threatening coronary artery-related pathology characterized by sudden cardiac death, often leading to cardiac fibrosis and heart failure (HF). Despite advances in emergency care and treatment measures such as percutaneous coronary intervention (PCI), the...

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Bibliographic Details
Main Authors: Wenyang Nie, Zhijie Zhao, Zhikai Xiahou, Jingwen Zhang, Yuhang Liu, Yong Wang, Zhen Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Single-cell RNA sequencing
Myocardial infarction
Fibroblasts
Myocardial fibrosis
Postn
Online Access:https://doi.org/10.1038/s41598-025-04990-6
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