The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk
Abstract The biomarkers associated with sepsis have not yet been completely elucidated. The objective of the current article is to investigate whether inflammatory factors act as risk factors for sepsis. The study included 320 adult patients with sepsis, which were enrolled as experimental group. In...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-90995-0 |
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| author | Shubao Wang Tianyu Liang Chulei Zhang |
| author_facet | Shubao Wang Tianyu Liang Chulei Zhang |
| author_sort | Shubao Wang |
| collection | DOAJ |
| description | Abstract The biomarkers associated with sepsis have not yet been completely elucidated. The objective of the current article is to investigate whether inflammatory factors act as risk factors for sepsis. The study included 320 adult patients with sepsis, which were enrolled as experimental group. In addition, 560 healthy individuals from the same period were selected as the control group. Cytokine expressions were measured using flow cytometry with fluorescence, and gene polymorphisms were analyzed through the PCR-RFLP technique. Significantly higher expression levels of IL-1, IL-6, IL-10, and TNF-α, were detected (p < 0.05). This study also identified specific polymorphisms IL-1B -511 C/T, IL-10 -1082 G/A, IL-6 -174 G/C, and TNF-α -308 G/A, that were significantly associated with an increased risk of sepsis (p < 0.05). The expression levels of IL-1, IL-6, IL-10, and TNF-α are associated with an increased risk of sepsis. Additionally, the polymorphisms IL-1B -511 C/T, IL-6 -174 G/C, IL-10 -1082 G/A, IFN-γ + 874 A/T, and TNF-α -308 G/A are also linked to sepsis risk in the Chinese population. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-b0fee3af510340dba4ebb62ce7e0f5282025-08-20T03:03:57ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-90995-0The relationship between expression level and gene polymorphism of inflammatory factors and sepsis riskShubao Wang0Tianyu Liang1Chulei Zhang2Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital)Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital)Intensive Care Unit, Haiyan People’s HospitalAbstract The biomarkers associated with sepsis have not yet been completely elucidated. The objective of the current article is to investigate whether inflammatory factors act as risk factors for sepsis. The study included 320 adult patients with sepsis, which were enrolled as experimental group. In addition, 560 healthy individuals from the same period were selected as the control group. Cytokine expressions were measured using flow cytometry with fluorescence, and gene polymorphisms were analyzed through the PCR-RFLP technique. Significantly higher expression levels of IL-1, IL-6, IL-10, and TNF-α, were detected (p < 0.05). This study also identified specific polymorphisms IL-1B -511 C/T, IL-10 -1082 G/A, IL-6 -174 G/C, and TNF-α -308 G/A, that were significantly associated with an increased risk of sepsis (p < 0.05). The expression levels of IL-1, IL-6, IL-10, and TNF-α are associated with an increased risk of sepsis. Additionally, the polymorphisms IL-1B -511 C/T, IL-6 -174 G/C, IL-10 -1082 G/A, IFN-γ + 874 A/T, and TNF-α -308 G/A are also linked to sepsis risk in the Chinese population.https://doi.org/10.1038/s41598-025-90995-0SepsisInflammatory factorsGene expressionGene polymorphism |
| spellingShingle | Shubao Wang Tianyu Liang Chulei Zhang The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk Scientific Reports Sepsis Inflammatory factors Gene expression Gene polymorphism |
| title | The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk |
| title_full | The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk |
| title_fullStr | The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk |
| title_full_unstemmed | The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk |
| title_short | The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk |
| title_sort | relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk |
| topic | Sepsis Inflammatory factors Gene expression Gene polymorphism |
| url | https://doi.org/10.1038/s41598-025-90995-0 |
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