Inflammatory Cytokines in Diabetic Nephropathy
Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in th...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/948417 |
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| _version_ | 1849395247304409088 |
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| author | Javier Donate-Correa Ernesto Martín-Núñez Mercedes Muros-de-Fuentes Carmen Mora-Fernández Juan F. Navarro-González |
| author_facet | Javier Donate-Correa Ernesto Martín-Núñez Mercedes Muros-de-Fuentes Carmen Mora-Fernández Juan F. Navarro-González |
| author_sort | Javier Donate-Correa |
| collection | DOAJ |
| description | Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of renal injury in patients with diabetes mellitus. However, the exact pathogenic mechanisms and the molecular events of diabetic nephropathy remain incompletely understood. Nowadays, there are convincing data that relate the diabetes inflammatory component with the development of renal disease. This review is focused on the inflammatory processes that develop diabetic nephropathy and on the new therapeutic approaches with anti-inflammatory effects for the treatment of chronic kidney disease in the setting of diabetic nephropathy. |
| format | Article |
| id | doaj-art-adce41c8f4e749d5bafff23f4a403d33 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-adce41c8f4e749d5bafff23f4a403d332025-08-20T03:39:41ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/948417948417Inflammatory Cytokines in Diabetic NephropathyJavier Donate-Correa0Ernesto Martín-Núñez1Mercedes Muros-de-Fuentes2Carmen Mora-Fernández3Juan F. Navarro-González4Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainResearch Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainClinical Biochemistry Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainResearch Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainResearch Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainProbably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of renal injury in patients with diabetes mellitus. However, the exact pathogenic mechanisms and the molecular events of diabetic nephropathy remain incompletely understood. Nowadays, there are convincing data that relate the diabetes inflammatory component with the development of renal disease. This review is focused on the inflammatory processes that develop diabetic nephropathy and on the new therapeutic approaches with anti-inflammatory effects for the treatment of chronic kidney disease in the setting of diabetic nephropathy.http://dx.doi.org/10.1155/2015/948417 |
| spellingShingle | Javier Donate-Correa Ernesto Martín-Núñez Mercedes Muros-de-Fuentes Carmen Mora-Fernández Juan F. Navarro-González Inflammatory Cytokines in Diabetic Nephropathy Journal of Diabetes Research |
| title | Inflammatory Cytokines in Diabetic Nephropathy |
| title_full | Inflammatory Cytokines in Diabetic Nephropathy |
| title_fullStr | Inflammatory Cytokines in Diabetic Nephropathy |
| title_full_unstemmed | Inflammatory Cytokines in Diabetic Nephropathy |
| title_short | Inflammatory Cytokines in Diabetic Nephropathy |
| title_sort | inflammatory cytokines in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2015/948417 |
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