Severe alpha-1 antitrypsin deficiency is associated with a higher risk of complications after first decompensation than other aetiologies of cirrhosis

Severe alpha-1 antitrypsin deficiency is associated with a higher risk of complications after first decompensation than other aetiologies of cirrhosis

Background & Aims: Alpha-1 antitrypsin deficiency (AATD) causes/predisposes to advanced chronic liver disease. However, the role of the SERPINA1 Pi∗ZZ genotype in patients with decompensated cirrhosis is unclear. Thus, we evaluated the impact of the Pi∗ZZ genotype on the disease course after...

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Main Authors: Lorenz Balcar, Malin Fromme, Naomi Kappe, Benedikt Schaefer, Soňa Fraňková, Lukas van Melkebeke, Jan Stolk, Mathias Jachs, Georg Semmler, Benedikt S. Hofer, Tammo L. Tergast, Hannah Rieland, Anna Sophie Karl, Jan Sperl, Martin Wagner, Mònica Pons, Harald Hofer, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger, Benjamin Maasoumy, Heinz Zoller, Bart van Hoek, Jef Verbeek, Pavel Strnad, Mattias Mandorfer
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:JHEP Reports
Subjects:
AATD
advanced chronic liver disease
portal hypertension
ascites
variceal bleeding
hepatic encephalopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000758
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