Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen

ABSTRACT In Borrelia burgdorferi, the causative agent of Lyme disease, differential gene expression is primarily governed by the alternative sigma factor RpoS (σS). Understanding the regulation of RpoS is crucial for elucidating how B. burgdorferi is maintained throughout its enzootic cycle. Our rec...

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Main Authors: Sajith Raghunandanan, Raj Priya, Gaofeng Lin, Fuad Alanazi, Andrew Zoss, Elise Warren, Philip Stewart, X. Frank Yang
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
Subjects:
Lyme disease
Borrelia burgdorferi
RpoS
BosR
tick-borne pathogens
Online Access:https://journals.asm.org/doi/10.1128/mbio.02766-24
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https://journals.asm.org/doi/10.1128/mbio.02766-24

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