Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan
Background: The epidemiology of nontyphoidal Salmonella (NTS) resistant to ciprofloxacin or ceftriaxone and its impact on patients’ clinical course are rarely reported. Methods: Children with culture-proven salmonellosis treated in a medical center in northern Taiwan in 2017 were enrolled. To trace...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957220300577 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849727540499841024 |
|---|---|
| author | Yi-Jung Chang Mi-Chi Chen Ye Feng Lin-Hui Su Hsin-Chieh Li Hsin-Ping Yang Min-Jia Yu Chyi-Liang Chen Cheng-Hsun Chiu |
| author_facet | Yi-Jung Chang Mi-Chi Chen Ye Feng Lin-Hui Su Hsin-Chieh Li Hsin-Ping Yang Min-Jia Yu Chyi-Liang Chen Cheng-Hsun Chiu |
| author_sort | Yi-Jung Chang |
| collection | DOAJ |
| description | Background: The epidemiology of nontyphoidal Salmonella (NTS) resistant to ciprofloxacin or ceftriaxone and its impact on patients’ clinical course are rarely reported. Methods: Children with culture-proven salmonellosis treated in a medical center in northern Taiwan in 2017 were enrolled. To trace the source of Salmonella, Salmonella isolated from food samples were collected from markets. Antimicrobial susceptibility and serotypes were determined. Results: Among the 453 isolates, 122 (26.9%) were highly antimicrobial-resistant, as defined by resistance to ciprofloxacin or ceftriaxone or both. The most prevalent highly resistant serotype was S. Anatum (66, 54.1%). Salmonella was detected in 94.1%, 66.7%, and 8.6% of examined pork, chicken, and vegetables examined, respectively. S. Anatum (6, 21.4%) and S. Derby (6, 21.4%) were the major serotypes isolated. Majority of the S. Anatum (5, 83.3%) were highly antimicrobial-resistant. More patients infected by highly resistant Salmonella required carbapenem treatment (OR = 23.5, 95% confidence interval [CI] 2.8–192.7, P < 0.001). Patients with ceftriaxone-resistant NTS infections had a significantly longer hospital stay than others (P < 0.001). Totally, 34 (7.5%) presented with invasive diseases (31 bacteremia, 1 intestinal perforation, 1 toxic megacolon and 1 septic arthritis). Risk factors for invasive disease included prolonged fever for ≧5 days and infection occurring in warmer season from May to October. The rise of ambient temperature in northern Taiwan was associated with increasing Salmonella infections. Conclusions: Retail meats were the main source of highly antimicrobial-resistant NTS in northern Taiwan. Highly antimicrobial resistance significantly impacted the clinical course and treatment of children with NTS infection. |
| format | Article |
| id | doaj-art-a4d165e9b53f4e2ba31ad7fd38c22e8d |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-a4d165e9b53f4e2ba31ad7fd38c22e8d2025-08-20T03:09:48ZengElsevierPediatrics and Neonatology1875-95722020-08-0161443243810.1016/j.pedneo.2020.03.017Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, TaiwanYi-Jung Chang0Mi-Chi Chen1Ye Feng2Lin-Hui Su3Hsin-Chieh Li4Hsin-Ping Yang5Min-Jia Yu6Chyi-Liang Chen7Cheng-Hsun Chiu8Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, TaiwanSir Run Run Shaw Hospital, Hangzhou, China; Institute for Translational Medicine, Zhejiang University School of Medicine, Hangzhou, ChinaMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Corresponding author. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan 333, Taiwan.Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan 333, Taiwan.Background: The epidemiology of nontyphoidal Salmonella (NTS) resistant to ciprofloxacin or ceftriaxone and its impact on patients’ clinical course are rarely reported. Methods: Children with culture-proven salmonellosis treated in a medical center in northern Taiwan in 2017 were enrolled. To trace the source of Salmonella, Salmonella isolated from food samples were collected from markets. Antimicrobial susceptibility and serotypes were determined. Results: Among the 453 isolates, 122 (26.9%) were highly antimicrobial-resistant, as defined by resistance to ciprofloxacin or ceftriaxone or both. The most prevalent highly resistant serotype was S. Anatum (66, 54.1%). Salmonella was detected in 94.1%, 66.7%, and 8.6% of examined pork, chicken, and vegetables examined, respectively. S. Anatum (6, 21.4%) and S. Derby (6, 21.4%) were the major serotypes isolated. Majority of the S. Anatum (5, 83.3%) were highly antimicrobial-resistant. More patients infected by highly resistant Salmonella required carbapenem treatment (OR = 23.5, 95% confidence interval [CI] 2.8–192.7, P < 0.001). Patients with ceftriaxone-resistant NTS infections had a significantly longer hospital stay than others (P < 0.001). Totally, 34 (7.5%) presented with invasive diseases (31 bacteremia, 1 intestinal perforation, 1 toxic megacolon and 1 septic arthritis). Risk factors for invasive disease included prolonged fever for ≧5 days and infection occurring in warmer season from May to October. The rise of ambient temperature in northern Taiwan was associated with increasing Salmonella infections. Conclusions: Retail meats were the main source of highly antimicrobial-resistant NTS in northern Taiwan. Highly antimicrobial resistance significantly impacted the clinical course and treatment of children with NTS infection.http://www.sciencedirect.com/science/article/pii/S1875957220300577nontyphoidal salmonellaserotypehighly antimicrobial resistanceinvasive salmonellosis |
| spellingShingle | Yi-Jung Chang Mi-Chi Chen Ye Feng Lin-Hui Su Hsin-Chieh Li Hsin-Ping Yang Min-Jia Yu Chyi-Liang Chen Cheng-Hsun Chiu Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan Pediatrics and Neonatology nontyphoidal salmonella serotype highly antimicrobial resistance invasive salmonellosis |
| title | Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan |
| title_full | Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan |
| title_fullStr | Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan |
| title_full_unstemmed | Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan |
| title_short | Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan |
| title_sort | highly antimicrobial resistant nontyphoidal salmonella from retail meats and clinical impact in children taiwan |
| topic | nontyphoidal salmonella serotype highly antimicrobial resistance invasive salmonellosis |
| url | http://www.sciencedirect.com/science/article/pii/S1875957220300577 |
| work_keys_str_mv | AT yijungchang highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT michichen highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT yefeng highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT linhuisu highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT hsinchiehli highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT hsinpingyang highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT minjiayu highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT chyiliangchen highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan AT chenghsunchiu highlyantimicrobialresistantnontyphoidalsalmonellafromretailmeatsandclinicalimpactinchildrentaiwan |