DNA hypermethylation preceded by H3K27 trimethylation is linked to downregulation of gene expression in disuse muscle atrophy in male mice

Abstract Disuse muscle atrophy can result in downregulated gene expression vital to muscle integrity, yet the mechanisms driving this downregulation remain unclear. Epigenetic alterations regulate transcriptional potential, with repressive changes suppressing gene expression. This study explored epi...

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Bibliographic Details
Main Authors: Junya Shimizu, Fuminori Kawano
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.70317
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