Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp.
The genus <i>Daldinia</i> have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of <i>Daldinia</i> from January 1995 to June 2024, and 2...
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2024-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/10/12/833 |
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| author | Miao Yu Shiji Chen Jueying Shi Weikang Chen Yikang Qiu Jing Lan Shiyan Qu Jiayi Feng Ru Wang Fangru Lin Guolei Huang Caijuan Zheng |
| author_facet | Miao Yu Shiji Chen Jueying Shi Weikang Chen Yikang Qiu Jing Lan Shiyan Qu Jiayi Feng Ru Wang Fangru Lin Guolei Huang Caijuan Zheng |
| author_sort | Miao Yu |
| collection | DOAJ |
| description | The genus <i>Daldinia</i> have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of <i>Daldinia</i> from January 1995 to June 2024, and 280 compounds, including six major categories—terpenoids, alkaloids, polyketides, polyphenols, steroids, and other classes—are presented in this review. Among these metabolites, 196 were identified as new structures. Remarkably, 112 compounds exhibited a range of biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, and enzyme-inhibitory activities. This review highlights the bioactive metabolites discovered in the past three decades from the genus of <i>Daldinia</i> while also exploring the potential of these symbiotic fungi as rich sources of novel and diverse natural products. The varying bioactivities of these metabolites offer a vast array of promising lead compounds and also could significantly contribute to the development of new medicines. |
| format | Article |
| id | doaj-art-a3dce4fa3b6e45e88d0b1cf91a202679 |
| institution | Kabale University |
| issn | 2309-608X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-a3dce4fa3b6e45e88d0b1cf91a2026792024-12-27T14:33:53ZengMDPI AGJournal of Fungi2309-608X2024-12-01101283310.3390/jof10120833Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp.Miao Yu0Shiji Chen1Jueying Shi2Weikang Chen3Yikang Qiu4Jing Lan5Shiyan Qu6Jiayi Feng7Ru Wang8Fangru Lin9Guolei Huang10Caijuan Zheng11Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaThe genus <i>Daldinia</i> have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of <i>Daldinia</i> from January 1995 to June 2024, and 280 compounds, including six major categories—terpenoids, alkaloids, polyketides, polyphenols, steroids, and other classes—are presented in this review. Among these metabolites, 196 were identified as new structures. Remarkably, 112 compounds exhibited a range of biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, and enzyme-inhibitory activities. This review highlights the bioactive metabolites discovered in the past three decades from the genus of <i>Daldinia</i> while also exploring the potential of these symbiotic fungi as rich sources of novel and diverse natural products. The varying bioactivities of these metabolites offer a vast array of promising lead compounds and also could significantly contribute to the development of new medicines.https://www.mdpi.com/2309-608X/10/12/833<i>Daldinia</i> sp.secondary metabolitesbioactivity |
| spellingShingle | Miao Yu Shiji Chen Jueying Shi Weikang Chen Yikang Qiu Jing Lan Shiyan Qu Jiayi Feng Ru Wang Fangru Lin Guolei Huang Caijuan Zheng Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp. Journal of Fungi <i>Daldinia</i> sp. secondary metabolites bioactivity |
| title | Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp. |
| title_full | Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp. |
| title_fullStr | Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp. |
| title_full_unstemmed | Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp. |
| title_short | Structures and Biological Activities of Secondary Metabolites from <i>Daldinia</i> spp. |
| title_sort | structures and biological activities of secondary metabolites from i daldinia i spp |
| topic | <i>Daldinia</i> sp. secondary metabolites bioactivity |
| url | https://www.mdpi.com/2309-608X/10/12/833 |
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