Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study
Abstract Objective This study investigated copper (Cu) status in relation to abdominal obesity indices and liver function in patients with non-alcoholic fatty liver disease (NAFLD). This case-control study was carried out on 80 overweight/obese patients with NAFLD and 80 apparently healthy age, sex,...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s13104-024-07025-x |
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| author | Sara Arefhosseini Helda Tutunchi Seyed Rafie Arefhosseini Seyede Zoha Ghavami Mehrangiz Ebrahimi-Mameghani |
| author_facet | Sara Arefhosseini Helda Tutunchi Seyed Rafie Arefhosseini Seyede Zoha Ghavami Mehrangiz Ebrahimi-Mameghani |
| author_sort | Sara Arefhosseini |
| collection | DOAJ |
| description | Abstract Objective This study investigated copper (Cu) status in relation to abdominal obesity indices and liver function in patients with non-alcoholic fatty liver disease (NAFLD). This case-control study was carried out on 80 overweight/obese patients with NAFLD and 80 apparently healthy age, sex, and body mass index (BMI)-matched controls. A validated and reliable 168-item semi-quantitative food frequency questionnaire was completed for each subject and fasting serum levels of liver aminotransferases, ferritin, Cu and ceruloplasmin were assessed. Results Mean intakes of energy and carbophydrate were significantly lower in patients with NAFLD than the control group while mean protein intake was highre (p < 0.05). Although mean Cu intake was greater in cases than controls, low dietary intake of Cu was found in 7.5% and 32.5% of the cases and controls, respectively. Apart from serum levels of liver aminotransferases (p < 0.001) and ferritin (p = 0.010), no significant differences were found in serum levels of Cu and ceruloplasmin. Serum and dietary Cu were positively correlated with obesity indices and serum ceruloplasmin was correlated with waist to height ratio and ferritin only in cases (p < 0.05). Low Cu intake (< 0.95 mg/day) was more likely to increase the odds of NAFLD (p for trend = 0.002), after adjusting for potential confounders. |
| format | Article |
| id | doaj-art-a3764cf36e5441d7b293e15335522216 |
| institution | Kabale University |
| issn | 1756-0500 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| spelling | doaj-art-a3764cf36e5441d7b293e153355222162024-12-22T12:12:34ZengBMCBMC Research Notes1756-05002024-12-011711710.1186/s13104-024-07025-xCopper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control studySara Arefhosseini0Helda Tutunchi1Seyed Rafie Arefhosseini2Seyede Zoha Ghavami3Mehrangiz Ebrahimi-Mameghani4Student Research Committee, Tabriz University of Medical SciencesEndocrine Research Center, Tabriz University of Medical SciencesDepartment of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesNutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical SciencesAbstract Objective This study investigated copper (Cu) status in relation to abdominal obesity indices and liver function in patients with non-alcoholic fatty liver disease (NAFLD). This case-control study was carried out on 80 overweight/obese patients with NAFLD and 80 apparently healthy age, sex, and body mass index (BMI)-matched controls. A validated and reliable 168-item semi-quantitative food frequency questionnaire was completed for each subject and fasting serum levels of liver aminotransferases, ferritin, Cu and ceruloplasmin were assessed. Results Mean intakes of energy and carbophydrate were significantly lower in patients with NAFLD than the control group while mean protein intake was highre (p < 0.05). Although mean Cu intake was greater in cases than controls, low dietary intake of Cu was found in 7.5% and 32.5% of the cases and controls, respectively. Apart from serum levels of liver aminotransferases (p < 0.001) and ferritin (p = 0.010), no significant differences were found in serum levels of Cu and ceruloplasmin. Serum and dietary Cu were positively correlated with obesity indices and serum ceruloplasmin was correlated with waist to height ratio and ferritin only in cases (p < 0.05). Low Cu intake (< 0.95 mg/day) was more likely to increase the odds of NAFLD (p for trend = 0.002), after adjusting for potential confounders.https://doi.org/10.1186/s13104-024-07025-xCopperIronObesityNon-alcoholic fatty liverCase-control study |
| spellingShingle | Sara Arefhosseini Helda Tutunchi Seyed Rafie Arefhosseini Seyede Zoha Ghavami Mehrangiz Ebrahimi-Mameghani Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study BMC Research Notes Copper Iron Obesity Non-alcoholic fatty liver Case-control study |
| title | Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study |
| title_full | Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study |
| title_fullStr | Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study |
| title_full_unstemmed | Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study |
| title_short | Copper status and its relation to abdominal obesity indices and liver function in non-alcoholic fatty liver disease: a case-control study |
| title_sort | copper status and its relation to abdominal obesity indices and liver function in non alcoholic fatty liver disease a case control study |
| topic | Copper Iron Obesity Non-alcoholic fatty liver Case-control study |
| url | https://doi.org/10.1186/s13104-024-07025-x |
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