18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma
Abstract This study investigates the utility of 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) in assessing skull-base bone invasion (SBBI) and predicting treatment response in advanced nasopharyngeal carcinoma (NPC). A retrospective analysis was conducted on...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-81350-w |
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| author | Xingyu Mu Jingze Li Jingquan Huang Zhenzhen Wang Zuguo Li Xun Li Yu Jiang Zhipeng Zhou Wei Fu |
| author_facet | Xingyu Mu Jingze Li Jingquan Huang Zhenzhen Wang Zuguo Li Xun Li Yu Jiang Zhipeng Zhou Wei Fu |
| author_sort | Xingyu Mu |
| collection | DOAJ |
| description | Abstract This study investigates the utility of 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) in assessing skull-base bone invasion (SBBI) and predicting treatment response in advanced nasopharyngeal carcinoma (NPC). A retrospective analysis was conducted on 142 patients with newly diagnosed advanced NPC who underwent 18F-NaF PET/CT for initial staging from December 2020 to December 2023. 18F-NaF PET/CT scans were analyzed for uptake values at the skull-base bone, and these were correlated with treatment outcomes of primary tumor using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Statistical analyses involved Mann–Whitney U tests for group comparisons and logistic regression for evaluating risk factors. Higher 18F-NaF uptake at the skull-base bone was significantly associated with advanced T stages (p < 0.0001) and the presence of bone metastases (p = 0.01). Patients exhibiting complete response (CR) to treatment had significantly lower skull-base 18F-NaF uptake compared to those with non-CR (p < 0.001). Receiver operating characteristic (ROC) analysis identified an SUVmax > 10.0 and SUVmean > 5.2 as predictive of non-CR, with AUC values of 0.77 and 0.76, respectively. Univariate and multivariable analysis confirmed SUVmax as a significant predictor of treatment response (OR = 7.03, 95% CI: 1.97–25.13, p < 0.05). Elevated 18F-NaF uptake at the skull-base bone is predictive of poorer treatment outcomes, highlighting its potential as a prognostic biomarker in advanced NPC. This study demonstrates that 18F-NaF PET/CT is a valuable imaging modality for evaluating SBBI in NPC, offering metabolic information that complements the anatomical findings from MRI. |
| format | Article |
| id | doaj-art-a121aa2767eb43a789e90eb4b884fbfa |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-a121aa2767eb43a789e90eb4b884fbfa2024-12-01T12:20:59ZengNature PortfolioScientific Reports2045-23222024-11-0114111110.1038/s41598-024-81350-w18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinomaXingyu Mu0Jingze Li1Jingquan Huang2Zhenzhen Wang3Zuguo Li4Xun Li5Yu Jiang6Zhipeng Zhou7Wei Fu8Department of Nuclear Medicine, Affiliated Hospital of Guilin Medical UniversityDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical UniversityDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical UniversityDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical UniversityDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical UniversityDepartment of Radiology, Affiliated Hospital of Guilin Medical UniversityDepartment of Radiology, Affiliated Hospital of Guilin Medical UniversityDepartment of Radiology, Affiliated Hospital of Guilin Medical UniversityDepartment of Nuclear Medicine, Affiliated Hospital of Guilin Medical UniversityAbstract This study investigates the utility of 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) in assessing skull-base bone invasion (SBBI) and predicting treatment response in advanced nasopharyngeal carcinoma (NPC). A retrospective analysis was conducted on 142 patients with newly diagnosed advanced NPC who underwent 18F-NaF PET/CT for initial staging from December 2020 to December 2023. 18F-NaF PET/CT scans were analyzed for uptake values at the skull-base bone, and these were correlated with treatment outcomes of primary tumor using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Statistical analyses involved Mann–Whitney U tests for group comparisons and logistic regression for evaluating risk factors. Higher 18F-NaF uptake at the skull-base bone was significantly associated with advanced T stages (p < 0.0001) and the presence of bone metastases (p = 0.01). Patients exhibiting complete response (CR) to treatment had significantly lower skull-base 18F-NaF uptake compared to those with non-CR (p < 0.001). Receiver operating characteristic (ROC) analysis identified an SUVmax > 10.0 and SUVmean > 5.2 as predictive of non-CR, with AUC values of 0.77 and 0.76, respectively. Univariate and multivariable analysis confirmed SUVmax as a significant predictor of treatment response (OR = 7.03, 95% CI: 1.97–25.13, p < 0.05). Elevated 18F-NaF uptake at the skull-base bone is predictive of poorer treatment outcomes, highlighting its potential as a prognostic biomarker in advanced NPC. This study demonstrates that 18F-NaF PET/CT is a valuable imaging modality for evaluating SBBI in NPC, offering metabolic information that complements the anatomical findings from MRI.https://doi.org/10.1038/s41598-024-81350-w18F-NaFPET/CTSkull-base bone invasionNasopharyngeal carcinomaTreatment response |
| spellingShingle | Xingyu Mu Jingze Li Jingquan Huang Zhenzhen Wang Zuguo Li Xun Li Yu Jiang Zhipeng Zhou Wei Fu 18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma Scientific Reports 18F-NaF PET/CT Skull-base bone invasion Nasopharyngeal carcinoma Treatment response |
| title | 18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma |
| title_full | 18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma |
| title_fullStr | 18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma |
| title_full_unstemmed | 18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma |
| title_short | 18F-NaF uptake in skull-base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma |
| title_sort | 18f naf uptake in skull base bone as a predictor of treatment response in advanced nasopharyngeal carcinoma |
| topic | 18F-NaF PET/CT Skull-base bone invasion Nasopharyngeal carcinoma Treatment response |
| url | https://doi.org/10.1038/s41598-024-81350-w |
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