A pan-beta-coronavirus vaccine bearing conserved and asymptomatic B- and T-cell epitopes protects against highly pathogenic Delta and highly transmissible Omicron SARS-CoV-2 variants

A pan-beta-coronavirus vaccine bearing conserved and asymptomatic B- and T-cell epitopes protects against highly pathogenic Delta and highly transmissible Omicron SARS-CoV-2 variants

Over the last five years of the COVID-19 pandemic, the repetitive mutations and deletions in the SARS-CoV-2 genome, primarily targeting the Spike gene, resulted in the emergence of multiple viral variants and sub-variants. The non-updated mismatched Spike-based sub-unit vaccines are less effective d...

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Bibliographic Details
Main Authors: Hawa Vahed, Swayam Prakash, Afshana Quadiri, Izabela Coimbra Ibraim, Etinosa Omorogieva, Swena Patel, Jimmy Tadros, Emma Jane Liao, Lauren Lau, Aziz A. Chentoufi, Anthony B. Nesburn, Baruch D. Kuppermann, Jeffrey B. Ulmer, Daniel Gil, Lbachir BenMohamed
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Pan-coronavirus vaccine
SARS-CoV-2
COVID-19
epitopes
antibodies
T-cells
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2025.2527438
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