RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch

RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch

Abstract Background and objective Hyperinflammatory response in early stage of sepsis was the key factor leading to multi-organ injury. Therefore, exploring an effective therapy to attenuate or reverse hyperinflammation was the priority of sepsis treatment. Previous study from our team showed that r...

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Bibliographic Details
Main Authors: Yuefang Liu, Shujun Gao, Zhanghui Li, Lei Yin, Shiyao Ge, Yangjing Zhao, Hui Wang, Bing Wan, Qixiang Shao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Inflammation
Subjects:
Sepsis
Hepatic damage
Recombinant human interleukin-11 (rhIL-11)
Monocytic myeloid-derived suppressor cells (M-MDSCs)
mTORC1
STAT3
Online Access:https://doi.org/10.1186/s12950-025-00447-9
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