Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthes...

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Bibliographic Details
Main Authors: Jie Wen, Lingmao Zhao, Zhuohan Li, Chao Pi, Xianhu Feng, Peng Shi, Hongru Yang, Ligang Chen, Xiaodong Wang, Furong Liu, Yumeng Wei, Ling Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
monocarbonyl CU analogues
colon cancer
AKT
JNK
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1464626/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1464626/full

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