JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation

JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation

Background: Pain and depression are common complications in patients with advanced cancer, which significantly affects their quality of life and survival. Dysregulation of the JAK/STAT3 pathway in the central nervous system is associated with pain and brain inflammatory disorders, but its role in bo...

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Bibliographic Details
Main Authors: Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Brain Research Bulletin
Subjects:
Bone cancer pain
Depression
JAK/STAT3 signaling
Th17 differentiation
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025000309
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