Engine breakdown of lysosomes and related organelles and the resulting physiology
Late endosomes/lysosomes (LE/Lys) and lysosome related organelles (LROs) move dynamically through cells which involves many levels of regulation. To reach their destination, they need to connect to the motor proteins dynein-dynactin, kinesin or myosin for long-range bidirectional transport along mic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1575571/full |
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| author | Nina Bakker Marlieke L. M. Jongsma Jacques Neefjes |
| author_facet | Nina Bakker Marlieke L. M. Jongsma Jacques Neefjes |
| author_sort | Nina Bakker |
| collection | DOAJ |
| description | Late endosomes/lysosomes (LE/Lys) and lysosome related organelles (LROs) move dynamically through cells which involves many levels of regulation. To reach their destination, they need to connect to the motor proteins dynein-dynactin, kinesin or myosin for long-range bidirectional transport along microtubules and short-range movement along actin filaments. This connection depends on various factors at the microtubule, including the MAP- and tubulin-code, as well as adaptors, Rab GTPases and effector proteins marking the LE/Lys and LRO membranes. Mutations affecting this transport results in defective LE/Lys or LRO cargo delivery often resulting in skin, neurological and/or immunological diseases. How LE/Lys and LRO transport is orchestrated and how it fails in disease states, will be discussed. |
| format | Article |
| id | doaj-art-8f4ec2624c1a436789a9676cb15885c9 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-8f4ec2624c1a436789a9676cb15885c92025-08-20T03:20:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.15755711575571Engine breakdown of lysosomes and related organelles and the resulting physiologyNina BakkerMarlieke L. M. JongsmaJacques NeefjesLate endosomes/lysosomes (LE/Lys) and lysosome related organelles (LROs) move dynamically through cells which involves many levels of regulation. To reach their destination, they need to connect to the motor proteins dynein-dynactin, kinesin or myosin for long-range bidirectional transport along microtubules and short-range movement along actin filaments. This connection depends on various factors at the microtubule, including the MAP- and tubulin-code, as well as adaptors, Rab GTPases and effector proteins marking the LE/Lys and LRO membranes. Mutations affecting this transport results in defective LE/Lys or LRO cargo delivery often resulting in skin, neurological and/or immunological diseases. How LE/Lys and LRO transport is orchestrated and how it fails in disease states, will be discussed.https://www.frontiersin.org/articles/10.3389/fcell.2025.1575571/fulllysosomeslysosome-related organelles (LROs)transportkinesindyneinmicrotubules |
| spellingShingle | Nina Bakker Marlieke L. M. Jongsma Jacques Neefjes Engine breakdown of lysosomes and related organelles and the resulting physiology Frontiers in Cell and Developmental Biology lysosomes lysosome-related organelles (LROs) transport kinesin dynein microtubules |
| title | Engine breakdown of lysosomes and related organelles and the resulting physiology |
| title_full | Engine breakdown of lysosomes and related organelles and the resulting physiology |
| title_fullStr | Engine breakdown of lysosomes and related organelles and the resulting physiology |
| title_full_unstemmed | Engine breakdown of lysosomes and related organelles and the resulting physiology |
| title_short | Engine breakdown of lysosomes and related organelles and the resulting physiology |
| title_sort | engine breakdown of lysosomes and related organelles and the resulting physiology |
| topic | lysosomes lysosome-related organelles (LROs) transport kinesin dynein microtubules |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1575571/full |
| work_keys_str_mv | AT ninabakker enginebreakdownoflysosomesandrelatedorganellesandtheresultingphysiology AT marliekelmjongsma enginebreakdownoflysosomesandrelatedorganellesandtheresultingphysiology AT jacquesneefjes enginebreakdownoflysosomesandrelatedorganellesandtheresultingphysiology |