Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2

Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2

Excessive mitochondrial fission and a shift to a Warburg phenotype are hallmarks of pulmonary hypertension (PH), although the mechanistic link between these processes remains unclear. We show that in pulmonary arterial endothelial cells (PAEC), Drp1 overexpression induces mitochondrial fission and i...

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Bibliographic Details
Main Authors: Xutong Sun, Manivannan Yegambaram, Qing Lu, Alejandro E. Garcia Flores, Marissa D. Pokharel, Jamie Soto, Saurabh Aggarwal, Ting Wang, Jeffrey R. Fineman, Stephen M. Black
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Mitochondrial fission
Warburg effect
Drp1
HIF-1 alpha
PHD2
Hydrogen peroxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000424
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