Engineering a Mesoporous Silicon Nanoparticle Cage to Enhance Performance of a Phosphotriesterase Enzyme for Degradation of VX Nerve Agent

Engineering a Mesoporous Silicon Nanoparticle Cage to Enhance Performance of a Phosphotriesterase Enzyme for Degradation of VX Nerve Agent

Abstract The organophosphate (OP)‐hydrolyzing enzyme phosphotriesterase (PTE, variant L7ep‐3a) immobilized within a partially oxidized mesoporous silicon nanoparticle cage is synthesized and the catalytic performance of the enzyme@nanoparticle construct for hydrolysis of a simulant, dimethyl p‐nitro...

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Bibliographic Details
Main Authors: Yi‐Sheng Lu, Eduardo Reynoso Moreno, Yubin Huang, Ruhan Fan, Ashley T. Tucker, Linnzi K. Wright, Ronald A. Evans, Brooke M. Ahern, Donald E. Owens, Stephen A. Chappell, Dale J. Christensen, John Dresios, Michael J. Sailor
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
acetylcholinesterase activity assay
dermal protection
enzyme immobilization
enzyme stability
phosphotriesterase variant L7ep‐3a
Online Access:https://doi.org/10.1002/advs.202409535
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https://doi.org/10.1002/advs.202409535

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