The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration

The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration

Tumor-derived extracellular vesicles (EVs) play an important role in cancer progression. Neutral sphingomyelinases (nSMases) are lipid-modifying enzymes that modulate the secretion of EVs from cells. How nSMase activity and therefore ceramide generation affect the composition and functionality of se...

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Bibliographic Details
Main Authors: Dolma Choezom, Jan-Moritz Plum, Pradhipa Karuna M., Adi Danieli-Mackay, Christof Lenz, Phillipp Brockmeyer, Julia Christina Gross
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
cell migration
extracellular matrix
neutral sphingomyelinases
<i>SMPD2</i>
SMPD3
Online Access:https://www.mdpi.com/2073-4409/14/7/547
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