COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis
Background: While epidemiological data suggest a connection between atopic dermatitis (AD) and COVID-19, the molecular mechanisms underlying this relationship remain unclear. Objective: To investigate whether COVID-19-related CpGs may contribute to AD development and whether this association is medi...
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Elsevier
2025-01-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124001546 |
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| author | Zhenwei Tang, MD Yu Chen, MBBS Yuzhen Ouyang, MBBS Yu Peng, MD, PhD Xiaoyong Man, MD, PhD |
| author_facet | Zhenwei Tang, MD Yu Chen, MBBS Yuzhen Ouyang, MBBS Yu Peng, MD, PhD Xiaoyong Man, MD, PhD |
| author_sort | Zhenwei Tang, MD |
| collection | DOAJ |
| description | Background: While epidemiological data suggest a connection between atopic dermatitis (AD) and COVID-19, the molecular mechanisms underlying this relationship remain unclear. Objective: To investigate whether COVID-19-related CpGs may contribute to AD development and whether this association is mediated through the regulation of specific genes’ expression. Methods: We combined Mendelian randomization and transcriptome analysis for data-driven explorations. Results: Among the 172 CpGs -associated with COVID-19 infection, merely 3 of them exhibited significant impacts on the risk of AD, including cg04543273, cg11916609, and cg10636246. In the following analysis of the causal effects of CpGs and their related gene expression, cg04543273 inhibited LMAN2 expression. However, there was not a significant impact of cg11916609 and cg10636246 on the expression of their corresponding genes. Besides, transcriptome analysis suggested that LMAN2 expression was significantly upregulated among the COVID-19-infected population, and LMAN2 expression was obviously correlated with Type 2 helper cells across different post-infection time points. Conclusion: Overall, this study provides new insights of the COVID-19-related onset and exacerbation of AD-COVID-19-related epigenetic changes and their regulatory impact on transcription. A novel role of LMAN2 was proposed in the relationship between viral infection and AD. More studies are warranted to further explore the mechanism of LMAN2-related immunopathology. |
| format | Article |
| id | doaj-art-84bae295cde240a78f4385dcf55e6390 |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj-art-84bae295cde240a78f4385dcf55e63902025-01-17T04:49:17ZengElsevierWorld Allergy Organization Journal1939-45512025-01-01181101022COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysisZhenwei Tang, MD0Yu Chen, MBBS1Yuzhen Ouyang, MBBS2Yu Peng, MD, PhD3Xiaoyong Man, MD, PhD4Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. 88 Jiefang Road, Hangzhou, Zhejiang, China.Clinical Medicine Eight-year Program, Xiangya Hospital, Central South University, Changsha, ChinaClinical Medicine Eight-year Program, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Rheumatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author.Background: While epidemiological data suggest a connection between atopic dermatitis (AD) and COVID-19, the molecular mechanisms underlying this relationship remain unclear. Objective: To investigate whether COVID-19-related CpGs may contribute to AD development and whether this association is mediated through the regulation of specific genes’ expression. Methods: We combined Mendelian randomization and transcriptome analysis for data-driven explorations. Results: Among the 172 CpGs -associated with COVID-19 infection, merely 3 of them exhibited significant impacts on the risk of AD, including cg04543273, cg11916609, and cg10636246. In the following analysis of the causal effects of CpGs and their related gene expression, cg04543273 inhibited LMAN2 expression. However, there was not a significant impact of cg11916609 and cg10636246 on the expression of their corresponding genes. Besides, transcriptome analysis suggested that LMAN2 expression was significantly upregulated among the COVID-19-infected population, and LMAN2 expression was obviously correlated with Type 2 helper cells across different post-infection time points. Conclusion: Overall, this study provides new insights of the COVID-19-related onset and exacerbation of AD-COVID-19-related epigenetic changes and their regulatory impact on transcription. A novel role of LMAN2 was proposed in the relationship between viral infection and AD. More studies are warranted to further explore the mechanism of LMAN2-related immunopathology.http://www.sciencedirect.com/science/article/pii/S1939455124001546COVID-19Atopic dermatitisDNA methylationsLMAN2 proteinEpigenetics |
| spellingShingle | Zhenwei Tang, MD Yu Chen, MBBS Yuzhen Ouyang, MBBS Yu Peng, MD, PhD Xiaoyong Man, MD, PhD COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis World Allergy Organization Journal COVID-19 Atopic dermatitis DNA methylations LMAN2 protein Epigenetics |
| title | COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis |
| title_full | COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis |
| title_fullStr | COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis |
| title_full_unstemmed | COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis |
| title_short | COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis |
| title_sort | covid 19 related epigenetic changes and atopic dermatitis an exploratory analysis |
| topic | COVID-19 Atopic dermatitis DNA methylations LMAN2 protein Epigenetics |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124001546 |
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