Oncolytic virus V937 in combination with PD-1 blockade therapy to target immunologically quiescent liver and colorectal cancer

Oncolytic virus V937 in combination with PD-1 blockade therapy to target immunologically quiescent liver and colorectal cancer

V937 is an investigational, genetically unmodified Kuykendall strain of coxsackievirus A21, which has been evaluated in the clinic for advanced solid tumor malignancies. V937 specifically infects and lyses tumor cells that overexpress intercellular adhesion molecule-1 (ICAM-1). Intratumoral V937 as...

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Bibliographic Details
Main Authors: Thai Q. Tran, Jeff Grein, Mohammed Selman, Lakshmanan Annamalai, Jennifer H. Yearley, Wendy M. Blumenschein, Svetlana Sadekova, Alissa A. Chackerian, Uyen Phan, Janica C. Wong
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
oncolytic virus
coxsackievirus A21
V937
pembrolizumab
colorectal carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000493
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