Tracking chondrocyte-to-fibroblast transformation via changes in cell electrophysiology

Abstract Cultured chondrocytes have potential for cartilage regeneration to treat degenerative diseases. However, when explanted chondrocytes are cultured in monolayer, they are known to dedifferentiate over time, adopting a more fibroblastic phenotype. This greatly impacts both research and potenti...

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Bibliographic Details
Main Authors: Krista S. P. Clarke, Rebecca Lewis, Michael Pycraft Hughes, Fatima H. Labeed
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-98958-1
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