Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study
In this study, the researchers produced a pear paste using typical Dangshan pear fruits. The mechanism that enables the paste to treat cough and related inflammatory responses was systematically investigated using an ammonia-induced mice cough model. The pear paste and its polar extracts relieved co...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624004936 |
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| author | Min Xu Yuhui Yu Huixin Xu Meiqing Li |
| author_facet | Min Xu Yuhui Yu Huixin Xu Meiqing Li |
| author_sort | Min Xu |
| collection | DOAJ |
| description | In this study, the researchers produced a pear paste using typical Dangshan pear fruits. The mechanism that enables the paste to treat cough and related inflammatory responses was systematically investigated using an ammonia-induced mice cough model. The pear paste and its polar extracts relieved cough symptoms, as evidenced by 44.0%, 53.4%, and 47.2% decreases in cough frequency and 21.0%, 43.3%, and 53.4% increases in latent period for pear paste, ethyl acetate extract (EAE) and n-butanol extract (WBE), respectively. In addition, the paste and its polar extracts reduced lung injuries, including alveolar dilatation, alveolar wall damage, and airway thickening. The two polar extracts exhibited anti-inflammatory effects in the airway through the suppression of a Th1 cytokine (IFN-γ, significantly suppressed by 15.49% and 16.33% for EAE and WBE, separately). A spectrum-effect relationship analysis was conducted to identify arbutin, protocatechuic acid, chlorogenic acid and naringin as the primary bioactive substances contributing to the antitussive and anti-inflammatory activities of pear paste. |
| format | Article |
| id | doaj-art-8173190983d74554ae19ff78d190a95d |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-8173190983d74554ae19ff78d190a95d2024-11-16T05:10:38ZengElsevierJournal of Functional Foods1756-46462024-11-01122106491Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship studyMin Xu0Yuhui Yu1Huixin Xu2Meiqing Li3Anhui Vocational College of Grain Engineering, Hefei 230036, PR ChinaState Key Laboratory of Tea Biology and Utilization, Anhui Agriculture University, Hefei 230036, PR ChinaState Key Laboratory of Tea Biology and Utilization, Anhui Agriculture University, Hefei 230036, PR ChinaState Key Laboratory of Tea Biology and Utilization, Anhui Agriculture University, Hefei 230036, PR China; Corresponding author.In this study, the researchers produced a pear paste using typical Dangshan pear fruits. The mechanism that enables the paste to treat cough and related inflammatory responses was systematically investigated using an ammonia-induced mice cough model. The pear paste and its polar extracts relieved cough symptoms, as evidenced by 44.0%, 53.4%, and 47.2% decreases in cough frequency and 21.0%, 43.3%, and 53.4% increases in latent period for pear paste, ethyl acetate extract (EAE) and n-butanol extract (WBE), respectively. In addition, the paste and its polar extracts reduced lung injuries, including alveolar dilatation, alveolar wall damage, and airway thickening. The two polar extracts exhibited anti-inflammatory effects in the airway through the suppression of a Th1 cytokine (IFN-γ, significantly suppressed by 15.49% and 16.33% for EAE and WBE, separately). A spectrum-effect relationship analysis was conducted to identify arbutin, protocatechuic acid, chlorogenic acid and naringin as the primary bioactive substances contributing to the antitussive and anti-inflammatory activities of pear paste.http://www.sciencedirect.com/science/article/pii/S1756464624004936Pear pasteAntitussive effectInflammation responseSpectrum-effect relationship |
| spellingShingle | Min Xu Yuhui Yu Huixin Xu Meiqing Li Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study Journal of Functional Foods Pear paste Antitussive effect Inflammation response Spectrum-effect relationship |
| title | Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study |
| title_full | Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study |
| title_fullStr | Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study |
| title_full_unstemmed | Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study |
| title_short | Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study |
| title_sort | identification of active substances in pear paste for the treatment of cough in mice using spectrum effect relationship study |
| topic | Pear paste Antitussive effect Inflammation response Spectrum-effect relationship |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624004936 |
| work_keys_str_mv | AT minxu identificationofactivesubstancesinpearpasteforthetreatmentofcoughinmiceusingspectrumeffectrelationshipstudy AT yuhuiyu identificationofactivesubstancesinpearpasteforthetreatmentofcoughinmiceusingspectrumeffectrelationshipstudy AT huixinxu identificationofactivesubstancesinpearpasteforthetreatmentofcoughinmiceusingspectrumeffectrelationshipstudy AT meiqingli identificationofactivesubstancesinpearpasteforthetreatmentofcoughinmiceusingspectrumeffectrelationshipstudy |