Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study
Abstract Background Insulin resistance and obesity are significant factors contributing to the incidence of stroke. The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and o...
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BMC
2025-07-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02667-7 |
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| author | Shiming He Yinghao Kuang Xinfang Huang Yafei Jian Jinyan Zhang Wanfen Huang Yang Zou Guotai Sheng Wei Wang Hongyi Yang |
| author_facet | Shiming He Yinghao Kuang Xinfang Huang Yafei Jian Jinyan Zhang Wanfen Huang Yang Zou Guotai Sheng Wei Wang Hongyi Yang |
| author_sort | Shiming He |
| collection | DOAJ |
| description | Abstract Background Insulin resistance and obesity are significant factors contributing to the incidence of stroke. The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and obesity) and its cumulative exposure (CumTyG-WWI). Methods A total of 4,718 participants without baseline stroke history were included in this investigation, with new-onset stroke cases identified as the main study outcome. Cumulative exposure to the TyG-WWI was calculated based on repeated measurement data from the first and third waves of the national surveys. The relationships of TyG-WWI and CumTyG-WWI with stroke risk were examined using multivariable Cox regression, followed by validation in sensitivity analyses. Results Within a six-year median tracking period, 350 cases of stroke were documented among the research subjects. Following adjustment for confounding variables, the Cox regression analysis indicated progressively higher stroke risk with increasing TyG-WWI or CumTyG-WWI levels. Multiple sensitivity analyses further confirmed the robustness of these findings. Additionally, subgroup analysis results demonstrated significant differences in stroke risk associated with TyG-WWI and CumTyG-WWI across different age strata; specifically, individuals aged 45–59 years had a relatively higher stroke risk at similarly high levels of TyG-WWI and CumTyG-WWI compared to those aged ≥ 60 years. Conclusion Elevated baseline TyG-WWI was significantly associated with increased stroke risk. Moreover, the increasing cumulative exposure of TyG-WWI over time further elevates the risk of stroke occurrence. Graphic abstract |
| format | Article |
| id | doaj-art-80e5eead5a174f73af9a36dbc455fa03 |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | Lipids in Health and Disease |
| spelling | doaj-art-80e5eead5a174f73af9a36dbc455fa032025-08-20T03:46:29ZengBMCLipids in Health and Disease1476-511X2025-07-0124111310.1186/s12944-025-02667-7Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort studyShiming He0Yinghao Kuang1Xinfang Huang2Yafei Jian3Jinyan Zhang4Wanfen Huang5Yang Zou6Guotai Sheng7Wei Wang8Hongyi Yang9Jiangxi Medical College, Nanchang UniversityJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Provincial Geriatric Hospital, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeDiscipline Construction Office, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeAbstract Background Insulin resistance and obesity are significant factors contributing to the incidence of stroke. The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and obesity) and its cumulative exposure (CumTyG-WWI). Methods A total of 4,718 participants without baseline stroke history were included in this investigation, with new-onset stroke cases identified as the main study outcome. Cumulative exposure to the TyG-WWI was calculated based on repeated measurement data from the first and third waves of the national surveys. The relationships of TyG-WWI and CumTyG-WWI with stroke risk were examined using multivariable Cox regression, followed by validation in sensitivity analyses. Results Within a six-year median tracking period, 350 cases of stroke were documented among the research subjects. Following adjustment for confounding variables, the Cox regression analysis indicated progressively higher stroke risk with increasing TyG-WWI or CumTyG-WWI levels. Multiple sensitivity analyses further confirmed the robustness of these findings. Additionally, subgroup analysis results demonstrated significant differences in stroke risk associated with TyG-WWI and CumTyG-WWI across different age strata; specifically, individuals aged 45–59 years had a relatively higher stroke risk at similarly high levels of TyG-WWI and CumTyG-WWI compared to those aged ≥ 60 years. Conclusion Elevated baseline TyG-WWI was significantly associated with increased stroke risk. Moreover, the increasing cumulative exposure of TyG-WWI over time further elevates the risk of stroke occurrence. Graphic abstracthttps://doi.org/10.1186/s12944-025-02667-7Insulin resistanceObesityStrokeTriglyceride glucose-weight adjusted waist indexCohort study |
| spellingShingle | Shiming He Yinghao Kuang Xinfang Huang Yafei Jian Jinyan Zhang Wanfen Huang Yang Zou Guotai Sheng Wei Wang Hongyi Yang Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study Lipids in Health and Disease Insulin resistance Obesity Stroke Triglyceride glucose-weight adjusted waist index Cohort study |
| title | Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study |
| title_full | Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study |
| title_fullStr | Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study |
| title_full_unstemmed | Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study |
| title_short | Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study |
| title_sort | impact of triglyceride glucose weight adjusted waist index and its cumulative exposure on stroke risk a nationwide prospective cohort study |
| topic | Insulin resistance Obesity Stroke Triglyceride glucose-weight adjusted waist index Cohort study |
| url | https://doi.org/10.1186/s12944-025-02667-7 |
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