AXL and SRC in clear cell renal cell carcinoma: absence of mutations, rare alternative splicing events, but association of protein expression with poor prognosis

AXL and SRC in clear cell renal cell carcinoma: absence of mutations, rare alternative splicing events, but association of protein expression with poor prognosis

Abstract Novel treatment options for metastatic renal cell carcinomas (RCC) include specific MET inhibitors, GAS6/AXL inhibitors, and SRC inhibitors. The interplay between c‐MET, SRC, AXL expression, and their gene mutation patterns in different renal carcinoma subtypes is unclear. To improve the un...

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Bibliographic Details
Main Authors: Muriel D Brada, Tülay Karakulak, Peter Schraml, Martina Haberecker, Dorothea Rutishauser, Jeffrey S Ross, Daniel Eberli, Holger Moch
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:The Journal of Pathology: Clinical Research
Subjects:
renal cell carcinoma
gene expression
tyrosine kinase inhibitor
Online Access:https://doi.org/10.1002/2056-4538.70028
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