Effect of copper on liver and bone metabolism in malnutrition
This study was planned to investigate the effects of copper (Cu) deficiency on liver and bone metabolism in malnourished children. Serum total calcium (Ca), inorganic phosphorus (P), Ca/P, Cu/Ca, Cu/P ratios and alkaline phosphatase (ALP) activity values were analyzed. Aspartate aminotransfer...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
1994-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3629 |
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| _version_ | 1849772664538791936 |
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| author | A H Güler N Sapan B Ediz Z Genç K Ozkan |
| author_facet | A H Güler N Sapan B Ediz Z Genç K Ozkan |
| author_sort | A H Güler |
| collection | DOAJ |
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This study was planned to investigate the effects of copper (Cu) deficiency on liver and bone metabolism in malnourished children. Serum total calcium (Ca), inorganic phosphorus (P), Ca/P, Cu/Ca, Cu/P ratios and alkaline phosphatase (ALP) activity values were analyzed. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT) enzyme activities and the ALT/AST (De Ritis) ratio as well as their correlations with Cu were tested to determine liver function. The results of the study showed that Cu deficiency directly affects the organic matrix formation, and by the suppression of ALP activity, indirectly causes decalcification. In the liver, however, no direct effect of Cu deficiency was seen. Deterioration in liver function and Cu deficiency increased parallel with the severity of malnutrition. Thus we concluded that a correlation exists between Cu and the parameters that indicate liver function.
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| format | Article |
| id | doaj-art-7dff4bac8b484e059e80f6467238706f |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1994-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-7dff4bac8b484e059e80f6467238706f2025-08-20T03:02:15ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211994-07-01363Effect of copper on liver and bone metabolism in malnutritionA H Güler0N SapanB EdizZ GençK OzkanDepartment of Biochemistry, Uludag University Faculty of Medicine, Görükle, Bursa. This study was planned to investigate the effects of copper (Cu) deficiency on liver and bone metabolism in malnourished children. Serum total calcium (Ca), inorganic phosphorus (P), Ca/P, Cu/Ca, Cu/P ratios and alkaline phosphatase (ALP) activity values were analyzed. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT) enzyme activities and the ALT/AST (De Ritis) ratio as well as their correlations with Cu were tested to determine liver function. The results of the study showed that Cu deficiency directly affects the organic matrix formation, and by the suppression of ALP activity, indirectly causes decalcification. In the liver, however, no direct effect of Cu deficiency was seen. Deterioration in liver function and Cu deficiency increased parallel with the severity of malnutrition. Thus we concluded that a correlation exists between Cu and the parameters that indicate liver function. https://turkjpediatr.org/article/view/3629 |
| spellingShingle | A H Güler N Sapan B Ediz Z Genç K Ozkan Effect of copper on liver and bone metabolism in malnutrition The Turkish Journal of Pediatrics |
| title | Effect of copper on liver and bone metabolism in malnutrition |
| title_full | Effect of copper on liver and bone metabolism in malnutrition |
| title_fullStr | Effect of copper on liver and bone metabolism in malnutrition |
| title_full_unstemmed | Effect of copper on liver and bone metabolism in malnutrition |
| title_short | Effect of copper on liver and bone metabolism in malnutrition |
| title_sort | effect of copper on liver and bone metabolism in malnutrition |
| url | https://turkjpediatr.org/article/view/3629 |
| work_keys_str_mv | AT ahguler effectofcopperonliverandbonemetabolisminmalnutrition AT nsapan effectofcopperonliverandbonemetabolisminmalnutrition AT bediz effectofcopperonliverandbonemetabolisminmalnutrition AT zgenc effectofcopperonliverandbonemetabolisminmalnutrition AT kozkan effectofcopperonliverandbonemetabolisminmalnutrition |