Prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancer
Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) has been implicated in some tumor types, but its role in primary prostate cancer (PCa) remains unexplored. This study investigates the prognostic significance of PITPNC1 in PCa. RNA sequencing (RNA-seq), mutation data and clinical info...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2024-11-01
|
| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20230928-100/pdf/JOMH2024061204.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) has been
implicated in some tumor types, but its role in primary prostate cancer (PCa)
remains unexplored. This study investigates the prognostic significance of
PITPNC1 in PCa. RNA sequencing (RNA-seq), mutation data and clinical information
on PCa cohorts were retrieved from the The Cancer Genome Atlas Program (TCGA) and
Gene Expression Omnibus (GEO) databases. Data analysis revealed that PITPNC1
expression was significantly lower in PCa tissues compared to benign tissues, and
this reduced expression correlated with earlier biochemical recurrence and
decreased overall survival. Functional enrichment analysis indicated that PITPNC1
activates pathways related to cell adhesion and immune receptor signaling while
inhibiting RNA metabolism pathways. Additionally, high Tumor Protein P53
(TP53) mutation frequency was observed in the low PITPNC1 expression
group. In immunotherapy cohorts, lower PITPNC1 expression was associated with
poorer outcomes. Furthermore, Rucaparib was identified as a potential therapeutic
agent for patients with low PITPNC1 expression. Collectively, we identified
PITPNC1 as a promising prognostic marker in PCa. Its expression levels can
predict immunotherapy responses, and it holds potential as a target for precision
therapies. |
|---|---|
| ISSN: | 1875-6867 1875-6859 |