STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation
Currently, only two preeclampsia susceptibility genes (ACVR2A, STOX1) have been identified within confirmed regions with significant genome-wide linkage, although many genetic screens in multiple populations have been performed. In this paper, we focus on the STOX1 gene. The epigenetic status of thi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/521826 |
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| _version_ | 1850220415239061504 |
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| author | Marie van Dijk Cees B. M. Oudejans |
| author_facet | Marie van Dijk Cees B. M. Oudejans |
| author_sort | Marie van Dijk |
| collection | DOAJ |
| description | Currently, only two preeclampsia susceptibility genes (ACVR2A, STOX1) have been identified within confirmed regions with significant genome-wide linkage, although many genetic screens in multiple populations have been performed. In this paper, we focus on the STOX1 gene. The epigenetic status of this gene is discussed explaining the maternal transmission of the STOX1 susceptibility allele observed in preeclamptic families. The known upstream regulation and downstream effector genes of the transcription factor STOX1 are described. Finally, we propose a model in which we combine the cell type-specific and allele-specific effects of STOX1. This includes intrinsic effects (differential CpG island methylation) and extrinsic effects (regulation of effector genes). |
| format | Article |
| id | doaj-art-7b898c4e12b147cbb921bca496e86ba5 |
| institution | OA Journals |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-7b898c4e12b147cbb921bca496e86ba52025-08-20T02:07:05ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/521826521826STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth RetardationMarie van Dijk0Cees B. M. Oudejans1Department of Clinical Chemistry, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Clinical Chemistry, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsCurrently, only two preeclampsia susceptibility genes (ACVR2A, STOX1) have been identified within confirmed regions with significant genome-wide linkage, although many genetic screens in multiple populations have been performed. In this paper, we focus on the STOX1 gene. The epigenetic status of this gene is discussed explaining the maternal transmission of the STOX1 susceptibility allele observed in preeclamptic families. The known upstream regulation and downstream effector genes of the transcription factor STOX1 are described. Finally, we propose a model in which we combine the cell type-specific and allele-specific effects of STOX1. This includes intrinsic effects (differential CpG island methylation) and extrinsic effects (regulation of effector genes).http://dx.doi.org/10.1155/2011/521826 |
| spellingShingle | Marie van Dijk Cees B. M. Oudejans STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation Journal of Pregnancy |
| title | STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation |
| title_full | STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation |
| title_fullStr | STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation |
| title_full_unstemmed | STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation |
| title_short | STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation |
| title_sort | stox1 key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation |
| url | http://dx.doi.org/10.1155/2011/521826 |
| work_keys_str_mv | AT marievandijk stox1keyplayerintrophoblastdysfunctionunderlyingearlyonsetpreeclampsiawithgrowthretardation AT ceesbmoudejans stox1keyplayerintrophoblastdysfunctionunderlyingearlyonsetpreeclampsiawithgrowthretardation |