Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons

Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons

Abstract Major Depressive Disorder (MDD) is a common, complex disorder that is a leading cause of disability worldwide and a significant risk factor for suicide. In this study, we have performed the largest molecular analysis of MDD in postmortem human brains (846 samples across 458 individuals) in...

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Main Authors: Fernando S. Goes, Leonardo Collado-Torres, Peter P. Zandi, Louise Huuki-Myers, Ran Tao, Andrew E. Jaffe, Geo Pertea, Joo Heon Shin, Daniel R. Weinberger, Joel E. Kleinman, Thomas M. Hyde
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59115-4
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https://doi.org/10.1038/s41467-025-59115-4

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