The Daunomycin: Biosynthesis, Actions, and the Search for New Solutions to Enhance Production

The Daunomycin: Biosynthesis, Actions, and the Search for New Solutions to Enhance Production

Daunorubicin (DNR) is an anthracycline antibiotic originating from soil-dwelling actinobacteria extensively used to treat malignant tumors. Over the decades, extensive attempts were made to enhance the production of anthracyclines by introducing genetic modifications and mutations in combination wit...

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Bibliographic Details
Main Authors: Baveesh Pudhuvai, Karel Beneš, Vladislav Čurn, Andrea Bohata, Jana Lencova, Radka Vrzalova, Jan Barta, Vladimir Matha
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Microorganisms
Subjects:
daunomycin
anthracyclines
<i>Streptomyces</i>
efflux
autotoxicity
enhancement
Online Access:https://www.mdpi.com/2076-2607/12/12/2639
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