Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis
Objective To investigate the association between the maintenance regimens for immunotherapy and prognosis in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and different cranial MRI manifestations. Methods Diagnosis, treatment, and follow-up data were collected from 94 patient...
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Editorial Office of Journal of Precision Medicine
2024-12-01
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| Series: | 精准医学杂志 |
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| Online Access: | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1732259586309-400518568.pdf |
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| author | WANG Kemo, YAN Cuihua, JIANG Jing, LIU Xuewu |
| author_facet | WANG Kemo, YAN Cuihua, JIANG Jing, LIU Xuewu |
| author_sort | WANG Kemo, YAN Cuihua, JIANG Jing, LIU Xuewu |
| collection | DOAJ |
| description | Objective To investigate the association between the maintenance regimens for immunotherapy and prognosis in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and different cranial MRI manifestations. Methods Diagnosis, treatment, and follow-up data were collected from 94 patients with a confirmed diagnosis of anti-NMDAR encephalitis in Qilu Hospital from January 2016 to January 2021, and the features of the disease were compared between the positive MRI group (group M with 35 patients) and the negative MRI group (group N with 59 patients), as well as the association between the maintenance regimens for immunotherapy and the long-term prognosis of patients. Results After follow-up for 4-73 months, group M had a median fCASE score of 1 (0,3), with 24 patients exhibiting poor symptomatic prognosis, and group N had a median fCASE score of 0 (0,1), with 21 patients exhibiting poor symptomatic prognosis, suggesting that group N had a better prognosis than group M (P<0.05). In group M, the patients who received long-term (treatment duration ≥6 months) immunotherapy had abetter symptomatic prognosis (P<0.05), while in group N, there was no significant difference in treatment outcome between the patients receiving short-term (treatment duration <6 months) immunotherapy and those receivinglong-term immunotherapy (P>0.05). Conclusion Autoimmune encephalitis patients with related responsible lesions found by cranial MRI have a relatively poor prognosis and should receive a longerterm of maintenance regimen for immunotherapy. |
| format | Article |
| id | doaj-art-77ce9c689ba54f5c934f4a0de213a494 |
| institution | Kabale University |
| issn | 2096-529X |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Journal of Precision Medicine |
| record_format | Article |
| series | 精准医学杂志 |
| spelling | doaj-art-77ce9c689ba54f5c934f4a0de213a4942024-11-22T07:33:24ZzhoEditorial Office of Journal of Precision Medicine精准医学杂志2096-529X2024-12-0139648649010.13362/j.jpmed.202406004Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitisWANG Kemo, YAN Cuihua, JIANG Jing, LIU Xuewu0Carotid and Cerebrovascular Ultrasound, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaObjective To investigate the association between the maintenance regimens for immunotherapy and prognosis in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and different cranial MRI manifestations. Methods Diagnosis, treatment, and follow-up data were collected from 94 patients with a confirmed diagnosis of anti-NMDAR encephalitis in Qilu Hospital from January 2016 to January 2021, and the features of the disease were compared between the positive MRI group (group M with 35 patients) and the negative MRI group (group N with 59 patients), as well as the association between the maintenance regimens for immunotherapy and the long-term prognosis of patients. Results After follow-up for 4-73 months, group M had a median fCASE score of 1 (0,3), with 24 patients exhibiting poor symptomatic prognosis, and group N had a median fCASE score of 0 (0,1), with 21 patients exhibiting poor symptomatic prognosis, suggesting that group N had a better prognosis than group M (P<0.05). In group M, the patients who received long-term (treatment duration ≥6 months) immunotherapy had abetter symptomatic prognosis (P<0.05), while in group N, there was no significant difference in treatment outcome between the patients receiving short-term (treatment duration <6 months) immunotherapy and those receivinglong-term immunotherapy (P>0.05). Conclusion Autoimmune encephalitis patients with related responsible lesions found by cranial MRI have a relatively poor prognosis and should receive a longerterm of maintenance regimen for immunotherapy.https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1732259586309-400518568.pdfanti-n-methyl-d-aspartate receptor encephalitis|magnetic resonance imaging|immunotherapy|prognosis |
| spellingShingle | WANG Kemo, YAN Cuihua, JIANG Jing, LIU Xuewu Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis 精准医学杂志 anti-n-methyl-d-aspartate receptor encephalitis|magnetic resonance imaging|immunotherapy|prognosis |
| title | Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis |
| title_full | Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis |
| title_fullStr | Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis |
| title_full_unstemmed | Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis |
| title_short | Association between maintenance regimens for immunotherapy and prognosis in patients with MRI-positive or MRI-negative anti-N-methyl-D-aspartate receptor encephalitis |
| title_sort | association between maintenance regimens for immunotherapy and prognosis in patients with mri positive or mri negative anti n methyl d aspartate receptor encephalitis |
| topic | anti-n-methyl-d-aspartate receptor encephalitis|magnetic resonance imaging|immunotherapy|prognosis |
| url | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1732259586309-400518568.pdf |
| work_keys_str_mv | AT wangkemoyancuihuajiangjingliuxuewu associationbetweenmaintenanceregimensforimmunotherapyandprognosisinpatientswithmripositiveormrinegativeantinmethyldaspartatereceptorencephalitis |