Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry
Background Patients with Kawasaki disease (KD) with coronary artery involvement require long‐term cardiac care. Although respective evidence‐based recommendations are missing, cardiac catheterization is still considered the gold standard for diagnosing detailed coronary pathology. Therefore, to bett...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.034248 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850219137634140160 |
|---|---|
| author | Julia Weisser Leonie Arnold Wolfgang Wällisch Daniel Quandt Bernd Opgen‐Rhein Frank‐Thomas Riede Florentine Gräfe Jörg Michel Raoul Arnold Heike Schneider Daniel Tanase Ulrike Herberg Christoph Happel Mali Tietje Gleb Tarusinov Jochen Grohmann Johanna Hummel André Rudolph Nikolaus Haas André Jakob |
| author_facet | Julia Weisser Leonie Arnold Wolfgang Wällisch Daniel Quandt Bernd Opgen‐Rhein Frank‐Thomas Riede Florentine Gräfe Jörg Michel Raoul Arnold Heike Schneider Daniel Tanase Ulrike Herberg Christoph Happel Mali Tietje Gleb Tarusinov Jochen Grohmann Johanna Hummel André Rudolph Nikolaus Haas André Jakob |
| author_sort | Julia Weisser |
| collection | DOAJ |
| description | Background Patients with Kawasaki disease (KD) with coronary artery involvement require long‐term cardiac care. Although respective evidence‐based recommendations are missing, cardiac catheterization is still considered the gold standard for diagnosing detailed coronary pathology. Therefore, to better understand coronary artery pathology development, we conducted a survey to document and evaluate cardiac catheterization data in a European population. Methods and Results We retrospectively analyzed cardiac catheterization data from KD children from the year 2010 until April 2023. This registry covers basic acute‐phase clinical data, and more importantly, detailed information on morphology, distribution, and the development of coronary artery pathologies. A total of 164 mainly White patients (65% boys) were included. A relevant number of patients had no coronary artery aneurysm (CAA) at the cardiac catheterization, indicating that distal CAAs were almost exclusively detected alongside proximal CAAs. Patients with multiple CAAs revealed a significant positive correlation between the number of CAAs and their dimensions in diameter and in length. Location of the CAA within the coronary artery, age at onset of KD, or natal sex did not significantly influence CAA diameters, but CAAs were longer in older children and in boys. Conclusions That distal CAAs were only present together with proximal ones will hopefully reduce diagnostic CCs in patients with KD without echocardiographically detected proximal CAAs. Furthermore, this study gives valuable insights into dimensional specifics of CAAs in patients with KD. As an ongoing registry, future analyses will further explore long‐term outcomes and performed treatments, helping to refine clinical long‐term strategies for patients with KD. REGISTRATION URL: https://drks.de/; Unique Identifier: DRKS00031022. |
| format | Article |
| id | doaj-art-75dc17e7709145c896c25e8d6e105e13 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-75dc17e7709145c896c25e8d6e105e132025-08-20T02:07:28ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-11-01132110.1161/JAHA.124.034248Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease RegistryJulia Weisser0Leonie Arnold1Wolfgang Wällisch2Daniel Quandt3Bernd Opgen‐Rhein4Frank‐Thomas Riede5Florentine Gräfe6Jörg Michel7Raoul Arnold8Heike Schneider9Daniel Tanase10Ulrike Herberg11Christoph Happel12Mali Tietje13Gleb Tarusinov14Jochen Grohmann15Johanna Hummel16André Rudolph17Nikolaus Haas18André Jakob19Department of Pediatric Cardiology and Pediatric Intensive Care Ludwig‐Maximilians‐Universität München Munich GermanyDepartment of Pediatric Cardiology and Pediatric Intensive Care Ludwig‐Maximilians‐Universität München Munich GermanyDepartment of Pediatric Cardiology Universität Erlangen Erlangen GermanyDepartment of Pediatric Cardiology Kinderspital Zürich Zürich SwitzerlandDepartment of Pediatrics Charité Berlin Berlin GermanyDepartment of Pediatric Cardiology Herzzentrum Leipzig Leipzig GermanyDepartment of Pediatric Cardiology Herzzentrum Leipzig Leipzig GermanyDepartment of Pediatric Cardiology Pulmonology and Pediatric Intensive Care Medicine University Children’s Hospital Tübingen Tübingen GermanyDepartment of Pediatric Cardiology and Congenital Heart Disease Universitätsklinikum Heidelberg Heidelberg GermanyDepartment of Pediatric Cardiology andIntensive Care Medicine Georg August University Medical Center Göttingen GermanyDepartment of Pediatric Cardiology Deutsches Herzzentrum München Munich GermanyDepartment of Pediatric Cardiology and Congenital Heart Disease Universitätsklinikum RWTH Aachen Aachen GermanyDepartment of Pediatric Cardiology MH Hannover Hannover GermanyDepartment of Pediatric Cardiology Herzzentrum Duisburg Duisburg GermanyDepartment of Pediatric Cardiology Herzzentrum Duisburg Duisburg GermanyCenter of Congenital Heart Disease/Pediatric Cardiology Heart and Diabetes Center NRW University Clinic of Ruhr‐University Bochum Bad Oeynhausen GermanyCenter of Congenital Heart Disease/Pediatric Cardiology Heart and Diabetes Center NRW University Clinic of Ruhr‐University Bochum Bad Oeynhausen GermanyPediatric Heart Center Astrid Lindgren Children’s Hospital Karolinska University Hospital Stockholm SwedenDepartment of Pediatric Cardiology and Pediatric Intensive Care Ludwig‐Maximilians‐Universität München Munich GermanyDepartment of Pediatric Cardiology and Pediatric Intensive Care Ludwig‐Maximilians‐Universität München Munich GermanyBackground Patients with Kawasaki disease (KD) with coronary artery involvement require long‐term cardiac care. Although respective evidence‐based recommendations are missing, cardiac catheterization is still considered the gold standard for diagnosing detailed coronary pathology. Therefore, to better understand coronary artery pathology development, we conducted a survey to document and evaluate cardiac catheterization data in a European population. Methods and Results We retrospectively analyzed cardiac catheterization data from KD children from the year 2010 until April 2023. This registry covers basic acute‐phase clinical data, and more importantly, detailed information on morphology, distribution, and the development of coronary artery pathologies. A total of 164 mainly White patients (65% boys) were included. A relevant number of patients had no coronary artery aneurysm (CAA) at the cardiac catheterization, indicating that distal CAAs were almost exclusively detected alongside proximal CAAs. Patients with multiple CAAs revealed a significant positive correlation between the number of CAAs and their dimensions in diameter and in length. Location of the CAA within the coronary artery, age at onset of KD, or natal sex did not significantly influence CAA diameters, but CAAs were longer in older children and in boys. Conclusions That distal CAAs were only present together with proximal ones will hopefully reduce diagnostic CCs in patients with KD without echocardiographically detected proximal CAAs. Furthermore, this study gives valuable insights into dimensional specifics of CAAs in patients with KD. As an ongoing registry, future analyses will further explore long‐term outcomes and performed treatments, helping to refine clinical long‐term strategies for patients with KD. REGISTRATION URL: https://drks.de/; Unique Identifier: DRKS00031022.https://www.ahajournals.org/doi/10.1161/JAHA.124.034248cardiac catheterizationcoronary artery pathologyKawasaki diseaselong‐term cardiac careWhite |
| spellingShingle | Julia Weisser Leonie Arnold Wolfgang Wällisch Daniel Quandt Bernd Opgen‐Rhein Frank‐Thomas Riede Florentine Gräfe Jörg Michel Raoul Arnold Heike Schneider Daniel Tanase Ulrike Herberg Christoph Happel Mali Tietje Gleb Tarusinov Jochen Grohmann Johanna Hummel André Rudolph Nikolaus Haas André Jakob Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiac catheterization coronary artery pathology Kawasaki disease long‐term cardiac care White |
| title | Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry |
| title_full | Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry |
| title_fullStr | Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry |
| title_full_unstemmed | Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry |
| title_short | Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry |
| title_sort | specific morphology of coronary artery aneurysms in mainly white patients with kawasaki disease initial data from the cardiac catheterization in kawasaki disease registry |
| topic | cardiac catheterization coronary artery pathology Kawasaki disease long‐term cardiac care White |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.034248 |
| work_keys_str_mv | AT juliaweisser specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT leoniearnold specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT wolfgangwallisch specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT danielquandt specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT berndopgenrhein specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT frankthomasriede specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT florentinegrafe specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT jorgmichel specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT raoularnold specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT heikeschneider specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT danieltanase specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT ulrikeherberg specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT christophhappel specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT malitietje specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT glebtarusinov specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT jochengrohmann specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT johannahummel specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT andrerudolph specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT nikolaushaas specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry AT andrejakob specificmorphologyofcoronaryarteryaneurysmsinmainlywhitepatientswithkawasakidiseaseinitialdatafromthecardiaccatheterizationinkawasakidiseaseregistry |