Effect of a garlic drench on Galectin gene expression in ovine whole blood
Garlic, known for its immune-modulating and antibiotic properties, contains lectins that possess antimicrobial and immunomodulatory effects. Galectins (Gals), which bind β-galactosides, play a role in modulating immunity and pathological processes. It is hypothesized that garlic’s lectin components...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Animal Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10495398.2024.2344208 |
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| _version_ | 1846099257531039744 |
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| author | SreeNavya Inupala Md. Rasel Uzzaman Priyanka Pande Sowmya Jagana Mulumebet Worku |
| author_facet | SreeNavya Inupala Md. Rasel Uzzaman Priyanka Pande Sowmya Jagana Mulumebet Worku |
| author_sort | SreeNavya Inupala |
| collection | DOAJ |
| description | Garlic, known for its immune-modulating and antibiotic properties, contains lectins that possess antimicrobial and immunomodulatory effects. Galectins (Gals), which bind β-galactosides, play a role in modulating immunity and pathological processes. It is hypothesized that garlic’s lectin components interfere with animal lectins. St. Croix sheep, known for their resistance to parasites and adaptability, are influenced by dietary supplements for innate immunity. This study evaluated the impact of garlic drench on Galectin gene expression in St. Croix sheep. Adult non-lactating ewes received either garlic juice concentrate or sterile distilled water for four weeks. Blood samples were collected, and plasma and whole blood cells were separated. Galectin secretion was assessed using a Sheep-specific ELISA, while Galectin gene transcription was analyzed through real-time PCR. Garlic administration upregulated LGALS-3 gene expression and significantly increased total plasma protein concentration. Garlic supplementation also affected Galectin secretion, with Gal-1, Gal-3, and Gal-9 showing differential effects. |
| format | Article |
| id | doaj-art-74a684a5586342a699c331c9b747dd95 |
| institution | Kabale University |
| issn | 1049-5398 1532-2378 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Biotechnology |
| spelling | doaj-art-74a684a5586342a699c331c9b747dd952024-12-31T18:28:12ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782024-12-0135110.1080/10495398.2024.2344208Effect of a garlic drench on Galectin gene expression in ovine whole bloodSreeNavya Inupala0Md. Rasel Uzzaman1Priyanka Pande2Sowmya Jagana3Mulumebet Worku4Department of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USADepartment of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USADepartment of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USADepartment of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USADepartment of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC, USAGarlic, known for its immune-modulating and antibiotic properties, contains lectins that possess antimicrobial and immunomodulatory effects. Galectins (Gals), which bind β-galactosides, play a role in modulating immunity and pathological processes. It is hypothesized that garlic’s lectin components interfere with animal lectins. St. Croix sheep, known for their resistance to parasites and adaptability, are influenced by dietary supplements for innate immunity. This study evaluated the impact of garlic drench on Galectin gene expression in St. Croix sheep. Adult non-lactating ewes received either garlic juice concentrate or sterile distilled water for four weeks. Blood samples were collected, and plasma and whole blood cells were separated. Galectin secretion was assessed using a Sheep-specific ELISA, while Galectin gene transcription was analyzed through real-time PCR. Garlic administration upregulated LGALS-3 gene expression and significantly increased total plasma protein concentration. Garlic supplementation also affected Galectin secretion, with Gal-1, Gal-3, and Gal-9 showing differential effects.https://www.tandfonline.com/doi/10.1080/10495398.2024.2344208GarlicGalectinssheep |
| spellingShingle | SreeNavya Inupala Md. Rasel Uzzaman Priyanka Pande Sowmya Jagana Mulumebet Worku Effect of a garlic drench on Galectin gene expression in ovine whole blood Animal Biotechnology Garlic Galectins sheep |
| title | Effect of a garlic drench on Galectin gene expression in ovine whole blood |
| title_full | Effect of a garlic drench on Galectin gene expression in ovine whole blood |
| title_fullStr | Effect of a garlic drench on Galectin gene expression in ovine whole blood |
| title_full_unstemmed | Effect of a garlic drench on Galectin gene expression in ovine whole blood |
| title_short | Effect of a garlic drench on Galectin gene expression in ovine whole blood |
| title_sort | effect of a garlic drench on galectin gene expression in ovine whole blood |
| topic | Garlic Galectins sheep |
| url | https://www.tandfonline.com/doi/10.1080/10495398.2024.2344208 |
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