Human induced pluripotent stem cell derived nanovesicles for cardiomyocyte protection and proliferation

Human induced pluripotent stem cell derived nanovesicles for cardiomyocyte protection and proliferation

It remains a significant challenge to reactivate the cell cycle activity of adult mammalian cardiomyocytes (CMs). This study created a hypo-immunogenic human induced pluripotent stem cell (hiPSC) line using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 gene editing to knockout β2...

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Bibliographic Details
Main Authors: Yuhua Wei, Xiaoxiao Geng, Qing You, Yu Zhang, Fangfang Cao, Gunaseelan Narayanan, Thanh Nguyen, Xiaoyuan Chen, Jianyi Zhang, Lei Ye
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-08-01
Series:Bioactive Materials
Subjects:
Pluripotent stem cells
Nanovesicles
Cell cycle
Myocardial protection
Regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25001562
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