Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging.
<h4>Purpose</h4>To assess the prognosis predictability of a measurable enhancing lesion using histogram parameters produced by the normalized cerebral blood volume (nCBV) and normalized apparent diffusion coefficient (nADC) after completion of standard concomitant chemoradiotherapy (CCRT...
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Public Library of Science (PLoS)
2014-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113587&type=printable |
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| author | Jae Hyun Kim Seung Hong Choi Inseon Ryoo Tae Jin Yun Tae Min Kim Se-Hoon Lee Chul-Kee Park Ji-Hoon Kim Chul-Ho Sohn Sung-Hye Park Il Han Kim |
| author_facet | Jae Hyun Kim Seung Hong Choi Inseon Ryoo Tae Jin Yun Tae Min Kim Se-Hoon Lee Chul-Kee Park Ji-Hoon Kim Chul-Ho Sohn Sung-Hye Park Il Han Kim |
| author_sort | Jae Hyun Kim |
| collection | DOAJ |
| description | <h4>Purpose</h4>To assess the prognosis predictability of a measurable enhancing lesion using histogram parameters produced by the normalized cerebral blood volume (nCBV) and normalized apparent diffusion coefficient (nADC) after completion of standard concomitant chemoradiotherapy (CCRT) and adjuvant temozolomide (TMZ) medication in glioblastoma multiforme (GBM) patients.<h4>Materials and methods</h4>This study was approved by the institutional review board (IRB), and the requirement for informed consent was waived. A total of 59 patients with newly diagnosed GBM who received standard CCRT with TMZ and adjuvant TMZ for six cycles underwent perfusion-weighted and diffusion-weighted imaging. Twenty-seven patients had a measurable enhancing lesion and 32 patients lacked a measurable enhancing lesion based on the Response Assessment in Neuro-Oncology (RANO) criteria in the follow-up MRI, which was performed within 3 months after adjuvant TMZ therapy was completed. We measured the nCBV and nADC histogram parameters based on the measurable enhancing lesion. The progression free survival (PFS) was analyzed by the Kaplan-Meier method with the use of the log-rank test.<h4>Results</h4>The median PFS of patients lacking measurable enhancing lesion was longer than for those with measurable enhancing lesions (17.6 vs 3.3 months, P<.0001). There was a significant, positive correlation between the 99th percentile nCBV value of a measurable enhancing lesion and the PFS (P= .044, R(2)= .152). In addition, the median PFS was longer in patients with a 99th percentile nCBV value ≧ 4.5 than it was in those with a value <4.5 (4.4 vs 3.1 months, P = .036).<h4>Conclusion</h4>We found that the nCBV value can be used for the prognosis prediction of a measurable enhancing lesion after the completion of standard treatment for GBM, wherein a high 99th percentile nCBV value (≧ 4.5) suggests a better PFS for GBM patients. |
| format | Article |
| id | doaj-art-72f98e8ef48849b9a7e5556f2cf72d9c |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-72f98e8ef48849b9a7e5556f2cf72d9c2025-08-20T03:01:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11358710.1371/journal.pone.0113587Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging.Jae Hyun KimSeung Hong ChoiInseon RyooTae Jin YunTae Min KimSe-Hoon LeeChul-Kee ParkJi-Hoon KimChul-Ho SohnSung-Hye ParkIl Han Kim<h4>Purpose</h4>To assess the prognosis predictability of a measurable enhancing lesion using histogram parameters produced by the normalized cerebral blood volume (nCBV) and normalized apparent diffusion coefficient (nADC) after completion of standard concomitant chemoradiotherapy (CCRT) and adjuvant temozolomide (TMZ) medication in glioblastoma multiforme (GBM) patients.<h4>Materials and methods</h4>This study was approved by the institutional review board (IRB), and the requirement for informed consent was waived. A total of 59 patients with newly diagnosed GBM who received standard CCRT with TMZ and adjuvant TMZ for six cycles underwent perfusion-weighted and diffusion-weighted imaging. Twenty-seven patients had a measurable enhancing lesion and 32 patients lacked a measurable enhancing lesion based on the Response Assessment in Neuro-Oncology (RANO) criteria in the follow-up MRI, which was performed within 3 months after adjuvant TMZ therapy was completed. We measured the nCBV and nADC histogram parameters based on the measurable enhancing lesion. The progression free survival (PFS) was analyzed by the Kaplan-Meier method with the use of the log-rank test.<h4>Results</h4>The median PFS of patients lacking measurable enhancing lesion was longer than for those with measurable enhancing lesions (17.6 vs 3.3 months, P<.0001). There was a significant, positive correlation between the 99th percentile nCBV value of a measurable enhancing lesion and the PFS (P= .044, R(2)= .152). In addition, the median PFS was longer in patients with a 99th percentile nCBV value ≧ 4.5 than it was in those with a value <4.5 (4.4 vs 3.1 months, P = .036).<h4>Conclusion</h4>We found that the nCBV value can be used for the prognosis prediction of a measurable enhancing lesion after the completion of standard treatment for GBM, wherein a high 99th percentile nCBV value (≧ 4.5) suggests a better PFS for GBM patients.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113587&type=printable |
| spellingShingle | Jae Hyun Kim Seung Hong Choi Inseon Ryoo Tae Jin Yun Tae Min Kim Se-Hoon Lee Chul-Kee Park Ji-Hoon Kim Chul-Ho Sohn Sung-Hye Park Il Han Kim Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging. PLoS ONE |
| title | Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging. |
| title_full | Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging. |
| title_fullStr | Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging. |
| title_full_unstemmed | Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging. |
| title_short | Prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging. |
| title_sort | prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients application of dynamic susceptibility contrast perfusion and diffusion weighted imaging |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113587&type=printable |
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