Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study
Background Studies have shown an association between the triglyceride–glucose (TyG) index and carotid artery plaque (CAP). However, the relationship between the TyG index and plaque burden in individuals with primary hypertension remains uncertain. Our study specifically aimed to explore this relati...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2024.2383232 |
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| author | Shanshan Liu Hao Zhang Miao Wu Zhixian Zhou Yao Xiao Qiang Wan Zhihui Lan Chao Rong |
| author_facet | Shanshan Liu Hao Zhang Miao Wu Zhixian Zhou Yao Xiao Qiang Wan Zhihui Lan Chao Rong |
| author_sort | Shanshan Liu |
| collection | DOAJ |
| description | Background Studies have shown an association between the triglyceride–glucose (TyG) index and carotid artery plaque (CAP). However, the relationship between the TyG index and plaque burden in individuals with primary hypertension remains uncertain. Our study specifically aimed to explore this relationship among primary hypertension patients.Methods This study involved 5,153 hospitalized patients diagnosed with primary hypertension who were undergoing treatment at the Affiliated Hospital of Jiangxi University of Chinese Medicine. We utilized multivariate logistic regression, penalized spline regression, and generalized additive models to assess the association between the TyG index and CAP burden.Results There were 2,400 patients with primary hypertension in all. The multivariate study, which took into account all covariables, showed a positive correlation between the TyG index and CAP (OR: 1.25, 95% CI: 1.04–1.5). When the TyG index was evaluated as quartiles, the risk of CAP in the Q3 and Q4 levels of the TyG index were 1.4 (95% CI: 1.03–1.91) and 1.54 (95% CI: 1.11–2.14) times greater than in the Q1 level after adjusting for all covariables (P for trend < .05). Regardless of whether the TyG index was used as a continuous variable or a categorical variable, it has no significant association with the risk of single plaque after adjusting for all confounders (p ≥ .05). The TyG index was found to be substantially correlated with the presence of multiple plaques when analyzed as a continuous variable (OR: 1.32, 95% CI: 1.09–1.59, p = .004). When the TyG index was evaluated as quartiles, the adjusted OR in Q3 and Q4 were 1.49 (95% CI: 1.06–2.1) and 1.67 (95% CI: 1.16–2.41), respectively, with Q1 as reference (P for trend = .005). The relationship between the TyG index and the presence of multiple plaques is also consistent in all subgroups.Conclusion The TyG index is positively associated with the presence of multiple plaques in patients with primary hypertension, whereas no association is found between the TyG index and the presence of a single carotid plaque. |
| format | Article |
| id | doaj-art-701a279e0ef94adf80acc299500af5e0 |
| institution | Kabale University |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-701a279e0ef94adf80acc299500af5e02024-12-16T03:46:05ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062024-12-0146110.1080/10641963.2024.2383232Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional studyShanshan Liu0Hao Zhang1Miao Wu2Zhixian Zhou3Yao Xiao4Qiang Wan5Zhihui Lan6Chao Rong7Department of Cardiology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaJiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaJiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaJiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaJiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaBackground Studies have shown an association between the triglyceride–glucose (TyG) index and carotid artery plaque (CAP). However, the relationship between the TyG index and plaque burden in individuals with primary hypertension remains uncertain. Our study specifically aimed to explore this relationship among primary hypertension patients.Methods This study involved 5,153 hospitalized patients diagnosed with primary hypertension who were undergoing treatment at the Affiliated Hospital of Jiangxi University of Chinese Medicine. We utilized multivariate logistic regression, penalized spline regression, and generalized additive models to assess the association between the TyG index and CAP burden.Results There were 2,400 patients with primary hypertension in all. The multivariate study, which took into account all covariables, showed a positive correlation between the TyG index and CAP (OR: 1.25, 95% CI: 1.04–1.5). When the TyG index was evaluated as quartiles, the risk of CAP in the Q3 and Q4 levels of the TyG index were 1.4 (95% CI: 1.03–1.91) and 1.54 (95% CI: 1.11–2.14) times greater than in the Q1 level after adjusting for all covariables (P for trend < .05). Regardless of whether the TyG index was used as a continuous variable or a categorical variable, it has no significant association with the risk of single plaque after adjusting for all confounders (p ≥ .05). The TyG index was found to be substantially correlated with the presence of multiple plaques when analyzed as a continuous variable (OR: 1.32, 95% CI: 1.09–1.59, p = .004). When the TyG index was evaluated as quartiles, the adjusted OR in Q3 and Q4 were 1.49 (95% CI: 1.06–2.1) and 1.67 (95% CI: 1.16–2.41), respectively, with Q1 as reference (P for trend = .005). The relationship between the TyG index and the presence of multiple plaques is also consistent in all subgroups.Conclusion The TyG index is positively associated with the presence of multiple plaques in patients with primary hypertension, whereas no association is found between the TyG index and the presence of a single carotid plaque.https://www.tandfonline.com/doi/10.1080/10641963.2024.2383232Triglyceride glucose indexcarotid artery plaquesingle plaquemultiple plaqueshypertensioncross-sectional study |
| spellingShingle | Shanshan Liu Hao Zhang Miao Wu Zhixian Zhou Yao Xiao Qiang Wan Zhihui Lan Chao Rong Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study Clinical and Experimental Hypertension Triglyceride glucose index carotid artery plaque single plaque multiple plaques hypertension cross-sectional study |
| title | Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study |
| title_full | Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study |
| title_fullStr | Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study |
| title_full_unstemmed | Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study |
| title_short | Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study |
| title_sort | association between the triglyceride glucose index and carotid artery plaque burden in patients with primary hypertension a cross sectional study |
| topic | Triglyceride glucose index carotid artery plaque single plaque multiple plaques hypertension cross-sectional study |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2024.2383232 |
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