Consistency and reproducibility of independent feedings using blood from two consecutive days at varying Plasmodium falciparum gametocyte densities based on both direct membrane feeding assay and direct skin feeding assay

Consistency and reproducibility of independent feedings using blood from two consecutive days at varying Plasmodium falciparum gametocyte densities based on both direct membrane feeding assay and direct skin feeding assay

Abstract Background New malaria control tools are needed to prevent the transmission of parasites from the host to the mosquito vector and vice versa. The infectiousness of Plasmodium falciparum gametocytes obtained from individuals to laboratory-reared mosquitoes should be quantified to employ easi...

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Main Authors: Hoseah Miima Akala, John J. Aponte, Millicent Anyango Achola, Dennis W. Juma, Benjamin H. Opot, Risper N. Maisiba, Raphael O. Okoth, Jackline A. Juma, Edwin W. Mwakio, Maurine A. Mwalo, David O. Oullo, David Abuom, Eric C. Garges, Fredrick L. Eyase, Lucas Otieno Tina, Nathanial K. Copeland, Amanda Roth, James Mutunga, Irene Onyango, Jaree Johnson, Bernhards R. Ogutu, Peter Sifuna, Jack Hutter, Laina Mercer, Mike Raine, Valerie Moore, Karen Ivinson, Yimin Wu, Ben Andagalu, Christian F. Ockenhouse
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Malaria Journal
Subjects:
Malaria
Gametocytes
Transmission blocking
Clinical trial design
Before-after
Online Access:https://doi.org/10.1186/s12936-025-05360-3
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