Functional significance of commonly regulated genes in mechanically and chemically induced retinal ganglion cell death in rat eyes

Functional significance of commonly regulated genes in mechanically and chemically induced retinal ganglion cell death in rat eyes

Abstract Despite much effort, the molecular mechanisms of retinal ganglion cell (RGC) death remain unclear. To identify common cell death-promoting machinery in the mechanically and chemically injured retina, we profiled temporal gene expression patterns and studied their functional roles in the rod...

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Bibliographic Details
Main Authors: Masaaki Kageyama, Koji Ohashi, Takashi Ota
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Retinal ganglion cell death
Microarray-based time-resolved gene expression profiling
Molecular annotation and functional validation
Cell death-promoting and intrinsic neuroprotective mechanisms
Protein tyrosine phosphatase
The proteasome
Online Access:https://doi.org/10.1038/s41598-025-09503-z
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https://doi.org/10.1038/s41598-025-09503-z

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