Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities

Abstract Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, and long-term stability of hematopoietic stem cells (HSCs). Recent research highlights the c...

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Bibliographic Details
Main Authors: Yun Liao, Stacia Octaviani, Zhen Tian, Samuel R. Wang, Chunlan Huang, Jian Huang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Stem Cell Research & Therapy
Subjects:
Mitochondrial quality control
Hematopoietic stem cell
Mitochondrial metabolism
Mitophagy
Mitochondrial biogenesis
Mitochondrial dynamics
Online Access:https://doi.org/10.1186/s13287-025-04304-7
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