Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings
<b>Objective</b>: Transperineal prostate (TP) biopsy is the key diagnostic tool for evaluating prostate cancer and is feasible under local anaesthetic (LA) alone. However, concerns about its tolerability encourage use of a multimodal analgesia approach. Pre-emptive over-the-counter analg...
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The Société Internationale d’Urologie (SIU)
2024-12-01
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| Series: | Société Internationale d’Urologie Journal |
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| Online Access: | https://www.mdpi.com/2563-6499/5/6/65 |
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| author | Shelley Ting-Li Wang Yuxi Xu Meredith J. Cheng Anika Jain Henry H. Woo |
| author_facet | Shelley Ting-Li Wang Yuxi Xu Meredith J. Cheng Anika Jain Henry H. Woo |
| author_sort | Shelley Ting-Li Wang |
| collection | DOAJ |
| description | <b>Objective</b>: Transperineal prostate (TP) biopsy is the key diagnostic tool for evaluating prostate cancer and is feasible under local anaesthetic (LA) alone. However, concerns about its tolerability encourage use of a multimodal analgesia approach. Pre-emptive over-the-counter analgesia with LA may provide a simple and low-risk option. The objective of this study was to investigate the effects of over-the-counter analgesia on TP biopsies conducted under LA. <b>Methods</b>: This interventional single-centre study investigated 160 participants who undertook a TP biopsy under LA, with and without pre-emptive analgesia (1 g of paracetamol and 400 mg of ibuprofen). Pain tolerability was measured using a visual analogue scale (VAS) at three procedural points (probe insertion, LA infiltration, and biopsy); an overall average VAS score was subsequently calculated. The abstracted secondary variables include patient details (age, prostate size, and PSA level), biopsy details (number of cores and volume of LA used), and preferability for LA use in future TP biopsies. An inferential statistical analysis was performed using Wilcoxon’s Rank Sum non-parametric test, Pearson’s test of correlation, and Pearson’s Chi-squared test. <b>Results</b>: The groups were comparable in age, prostate size, and PSA level. Median VAS scores were consistently lower in the intervention cohort, but without statistical significance. A higher volume of LA was associated with lower overall VAS (<i>p</i> = 0.03). LA was strongly preferred over GA for hypothetical future TP biopsies in both cohorts. <b>Conclusions</b>: Pre-emptive analgesia does not significantly improve tolerability of TP biopsy under LA. Our study substantiates evidence that TP biopsy is generally well tolerated under LA and preferred over GA. |
| format | Article |
| id | doaj-art-61876fbe7895414cbe7627b4142bed47 |
| institution | Kabale University |
| issn | 2563-6499 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Société Internationale d’Urologie (SIU) |
| record_format | Article |
| series | Société Internationale d’Urologie Journal |
| spelling | doaj-art-61876fbe7895414cbe7627b4142bed472024-12-27T14:53:42ZengThe Société Internationale d’Urologie (SIU)Société Internationale d’Urologie Journal2563-64992024-12-015685286410.3390/siuj5060065Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate FindingsShelley Ting-Li Wang0Yuxi Xu1Meredith J. Cheng2Anika Jain3Henry H. Woo4School of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra 0200, AustraliaSchool of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra 0200, AustraliaSchool of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra 0200, AustraliaDepartment of Urology, Sydney Adventist Hospital, Wahroonga 2076, AustraliaSchool of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra 0200, Australia<b>Objective</b>: Transperineal prostate (TP) biopsy is the key diagnostic tool for evaluating prostate cancer and is feasible under local anaesthetic (LA) alone. However, concerns about its tolerability encourage use of a multimodal analgesia approach. Pre-emptive over-the-counter analgesia with LA may provide a simple and low-risk option. The objective of this study was to investigate the effects of over-the-counter analgesia on TP biopsies conducted under LA. <b>Methods</b>: This interventional single-centre study investigated 160 participants who undertook a TP biopsy under LA, with and without pre-emptive analgesia (1 g of paracetamol and 400 mg of ibuprofen). Pain tolerability was measured using a visual analogue scale (VAS) at three procedural points (probe insertion, LA infiltration, and biopsy); an overall average VAS score was subsequently calculated. The abstracted secondary variables include patient details (age, prostate size, and PSA level), biopsy details (number of cores and volume of LA used), and preferability for LA use in future TP biopsies. An inferential statistical analysis was performed using Wilcoxon’s Rank Sum non-parametric test, Pearson’s test of correlation, and Pearson’s Chi-squared test. <b>Results</b>: The groups were comparable in age, prostate size, and PSA level. Median VAS scores were consistently lower in the intervention cohort, but without statistical significance. A higher volume of LA was associated with lower overall VAS (<i>p</i> = 0.03). LA was strongly preferred over GA for hypothetical future TP biopsies in both cohorts. <b>Conclusions</b>: Pre-emptive analgesia does not significantly improve tolerability of TP biopsy under LA. Our study substantiates evidence that TP biopsy is generally well tolerated under LA and preferred over GA.https://www.mdpi.com/2563-6499/5/6/65prostate cancertransperinealprostate biopsypain managementanalgesia |
| spellingShingle | Shelley Ting-Li Wang Yuxi Xu Meredith J. Cheng Anika Jain Henry H. Woo Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings Société Internationale d’Urologie Journal prostate cancer transperineal prostate biopsy pain management analgesia |
| title | Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings |
| title_full | Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings |
| title_fullStr | Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings |
| title_full_unstemmed | Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings |
| title_short | Tolerability of Transperineal Prostate Biopsy Under Local Anaesthetic Using Pre-Emptive Over-the-Counter Analgesia: An Interventional Study in Patients with Abnormal Clinical Prostate Findings |
| title_sort | tolerability of transperineal prostate biopsy under local anaesthetic using pre emptive over the counter analgesia an interventional study in patients with abnormal clinical prostate findings |
| topic | prostate cancer transperineal prostate biopsy pain management analgesia |
| url | https://www.mdpi.com/2563-6499/5/6/65 |
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