Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium

Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium

Abstract Background Human induced pluripotent stem cells represent a scalable source of youthful tissue progenitors and secretomes for regenerative therapies. The aim of our study was to investigate the potential of conditioned medium (CM) from hiPSC-mesenchymal progenitors (hiPSC-MPs) to stimulate...

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Main Authors: Darja Marolt Presen, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra-Larissa Stetco, Anja Tansek, Laura Pozenel, Bella Bruszel, Goran Mitulovic, Johannes Oesterreicher, Johannes Zipperle, Barbara Schaedl, Wolfgang Holnthoner, Johannes Grillari, Heinz Redl
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Stem Cell Research & Therapy
Subjects:
Conditioned medium
Secretome
Human iPSCs
Human bone marrow mesenchymal stromal cells
Mesenchymal progenitors
Osteogenic differentiation
Online Access:https://doi.org/10.1186/s13287-024-03960-5
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https://doi.org/10.1186/s13287-024-03960-5

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