Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis

Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis

Abstract Highly conserved homeobox genes are closely related to bone formation during embryogenesis, while their role in adult bone resorption remains unclear. In this study, we found that the homeobox gene MSX2 actively participates bone metabolism. Myeloid-specific Msx2 deficiency safeguards bone...

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Main Authors: Qingliang Ma, Shiyu Wang, Hong Xue, Linhui Ni, Putao Yuan, Yang Shen, Bingjie Zheng, Qingqing Wang, Jiateng Zhang, Haoming Wang, Hongwei Xie, Chao Jiang, An Qin, Shunwu Fan, Ziang Xie, Zhiwei Jie
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61938-0
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