Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size

Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size

Abstract The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation could improve the effectiveness of strategies aimed at HIV remission. Th...

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Bibliographic Details
Main Authors: Erick De La Torre Tarazona, Elisa Moraga, Raúl Vaquer, Sonsoles Sánchez-Palomino, Elisa de Lazzari, Laura Luna, Sònia Vicens-Artés, Lucio Jesús García Fraile, Joaquim Peraire, Mercedes Garcia-Gasalla, Luz Balsalobre, Sergio Guillén Martínez, Luis Fernando López Cortés, Inma Jarrín, Sergio Serrano-Villar, José Alcamí, Santiago Moreno, CoRIS Cohort
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Latency reversal agent
Timing of administration
HIV reservoir
Maraviroc
Antiretroviral Therapy
Online Access:https://doi.org/10.1038/s41598-025-09474-1
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