Clinical Benefits of Ibuprofen Arginine: A Narrative Review

Abstract Ibuprofen arginine (IBA) combines well-established analgesic and anti-inflammatory properties with enhanced pharmacokinetics. The addition of arginine significantly improves solubility and absorption, leading to a faster onset of action compared to conventional ibuprofen. Clinical studies c...

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Bibliographic Details
Main Authors: Piercarlo Sarzi-Puttini, Serge Perrot, Juan Perez-Cajaraville, Diego Maria Michele Fornasari, Franco Radaelli, Giustino Varrassi
Format: Article
Language:English
Published: Adis, Springer Healthcare 2025-04-01
Series:Pain and Therapy
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Online Access:https://doi.org/10.1007/s40122-025-00735-5
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Summary:Abstract Ibuprofen arginine (IBA) combines well-established analgesic and anti-inflammatory properties with enhanced pharmacokinetics. The addition of arginine significantly improves solubility and absorption, leading to a faster onset of action compared to conventional ibuprofen. Clinical studies consistently demonstrate that IBA achieves meaningful pain relief within a shorter timeframe while maintaining a favorable safety profile. IBA’s rapid action is particularly valuable in managing acute exacerbations of chronic pain and preventing central sensitization, thus improving patient comfort, adherence, and overall quality of life. By addressing both the inflammatory and nociceptive components of pain, IBA offers an effective and well-tolerated alternative in multimodal pain management strategies. This review explores the clinical benefits of IBA in pain management among various clinical settings.
ISSN:2193-8237
2193-651X